Skip to search formSkip to main contentSkip to account menu
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
TLDR
The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions, and seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease.
View on Nature
International Union of Pharmacology. XIII. Classification of histamine receptors.
TLDR
The classification of histamine receptors has to date been based on rigorous classical pharmacological analysis, and as yet, the classification of the three histamines receptors that have been defined by this process have not been added to because of lack of evidence.
View on PubMed
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
TLDR
It is reported that anandamide is produced in and released from cultured brain neurons in a calcium ion-dependent manner when the neurons are stimulated with membrane-depolarizing agents, indicating that multiple biochemical pathways may participate in an andamide formation in brain tissue.
View on Nature
Histaminergic transmission in the mammalian brain.
TLDR
Article de synthese sur le metabolisme de l'histamine, sur la localisation des voies neuronales and des recepteurs histaminergiques, dans le controle neuroendocrine dans la regulation cardiovasculaire.
View on PubMed
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist
TLDR
BP 897 inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects, which indicates that compounds like BP 897 could be used for reducing the drug craving and vulnerability to relapse that are elicited by drug- associated environmental stimuli.
View on Springer
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
TLDR
It is shown that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D3 receptor in nucleus accumbens both during development and in adulthood, and may be an important determinant of pathophysiological conditions such as drug addiction, schizophrenia or Parkinson's disease.
View on Springer
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor
TLDR
It is shown here that histamine inhibits its own release from depolarized slices of rat cerebral cortex, an action apparently mediated by a class of receptor (H3) pharmacologically distinct from those previously characterized, that is, the H1 and H2 receptors.
View on Springer
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
TLDR
Northern blot and in situ hybridization analyses showed the 5-HT7 transcripts to be expressed in discrete areas of the limbic brain (e.g., pyramidal hippocampus cells, tenia tecta, amygdaloid, or mammillary nuclei), suggesting that the receptor mediates serotoninergic controls in functions like mood, learning, or neuroendocrine and vegetative behaviors.
View on PubMed
Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa.
In rats with unilateral lesions of the nigrostriatal dopamine pathway with 6-hydroxydopamine, the motor stimulating effects of levodopa, an indirect dopamine receptor agonist, evidenced by…
View on PubMed
A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation.
TLDR
Cloned a rat cDNA encoding a functional serotonin receptor (5-HT6), its coding sequence corresponds to a glycoprotein of 436 amino acids displaying significant homology with other cloned monoaminergic receptors, e.g., various serotonin receptors.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License