J. Schwartz

Publications749
h-index105
Citations43,576
Highly Influential Citations1,260
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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
TLDR
The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions, and seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease. Expand
International Union of Pharmacology. XIII. Classification of histamine receptors.
The classification of histamine receptors has to date been based on rigorous classical pharmacological analysis, and as yet, the classification of the three histamine receptors that have been defined… Expand
Histaminergic transmission in the mammalian brain.
Article de synthese sur le metabolisme de l'histamine, sur la localisation des voies neuronales et des recepteurs histaminergiques. Role de l'histamine dans le controle neuroendocrine, dans la… Expand
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
TLDR
It is reported that anandamide is produced in and released from cultured brain neurons in a calcium ion-dependent manner when the neurons are stimulated with membrane-depolarizing agents, indicating that multiple biochemical pathways may participate in an andamide formation in brain tissue. Expand
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist
TLDR
BP 897 inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects, which indicates that compounds like BP 897 could be used for reducing the drug craving and vulnerability to relapse that are elicited by drug- associated environmental stimuli. Expand
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
TLDR
It is shown that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D3 receptor in nucleus accumbens both during development and in adulthood, and may be an important determinant of pathophysiological conditions such as drug addiction, schizophrenia or Parkinson's disease. Expand
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
TLDR
Northern blot and in situ hybridization analyses showed the 5-HT7 transcripts to be expressed in discrete areas of the limbic brain (e.g., pyramidal hippocampus cells, tenia tecta, amygdaloid, or mammillary nuclei), suggesting that the receptor mediates serotoninergic controls in functions like mood, learning, or neuroendocrine and vegetative behaviors. Expand
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor
TLDR
It is shown here that histamine inhibits its own release from depolarized slices of rat cerebral cortex, an action apparently mediated by a class of receptor (H3) pharmacologically distinct from those previously characterized, that is, the H1 and H2 receptors. Expand
Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin.
TLDR
Native D3 receptors in brain are characterized by an unusually high nanomolar affinity for dopamine and a low modulatory influence of guanyl nucleotides on agonist binding, which suggest that D3 receptor are involved in a peculiar mode of neurotransmission in a restricted subpopulation of dopamine neurons. Expand
Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa.
In rats with unilateral lesions of the nigrostriatal dopamine pathway with 6-hydroxydopamine, the motor stimulating effects of levodopa, an indirect dopamine receptor agonist, evidenced by… Expand
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