J. Costentin

Publications354
h-index48
Citations9,306
Highly Influential Citations288
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Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Adenosine is released from metabolically active cells by facilitated diffusion, and is generated extracellularly by degradation of released ATP. It is a potent biological mediator that modulates the… Expand
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Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity
A neuropeptide was isolated from a frog brain extract by HPLC purification and characterized by mass spectrometry. This 26-aa neuropeptide, which belongs to the RFamide peptide family, was designated… Expand
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Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions
When mice are introduced into an open-field, they are inclined to explore mainly the peripheral zone of this open-field. This tendency to remain close the walls, called thigmotaxis, decreases… Expand
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The Endomorphin System and Its Evolving Neurophysiological Role
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are two endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid receptor. The… Expand
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Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Food Intake in Mice Through Activation of the Hypothalamic Melanocortin System
Pituitary adenylate cyclase-activating polypeptide (PACAP) and the proopiomelanocortin (POMC)-derived peptide, α-melanocyte-stimulating hormone (α-MSH), exert anorexigenic activities. While α-MSH is… Expand
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Nociceptin stimulates locomotion and exploratory behaviour in mice.
The recently characterized heptadecapeptide nociceptin, the endogenous agonist of the orphan opioid receptor-like 1 (ORL1 receptor), has been tested for its effects on locomotion and exploratory… Expand
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Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice
Previously established dose-response curves indicated that modafinil 20-40 mg/kg i.p. elicited in mice an obvious stimulation of locomotor activity roughly similar to that induced by (+)amphetamine… Expand
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Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.
Nafadotride (N[(n-butyl-2-pyrrolidinyl)methyl]-1-methoxy-4-cyano naphtalene-2-carboxamide) is a novel compound, which inhibits potently and stereoselectively [125I]iodosulpride binding at recombinant… Expand
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The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes
The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently shown to inhibit NT binding to the cloned rat and human NT receptor and to antagonize NT effects in a variety of in vitro and in… Expand
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Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin
The neuropeptide neurotensin (NT) elicits hypothermic and naloxone-insensitive analgesic responses after brain injection. Recent pharmacological evidence obtained with NT agonists and antagonists… Expand
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