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- Publications
- Influence
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
- C. Ledent, J. Vaugeois, +7 authors M. Parmentier
- Chemistry, Medicine
- Nature
- 14 August 1997
Adenosine is released from metabolically active cells by facilitated diffusion, and is generated extracellularly by degradation of released ATP. It is a potent biological mediator that modulates the… Expand
Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity
- N. Chartrel, C. Dujardin, +9 authors H. Vaudry
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 December 2003
A neuropeptide was isolated from a frog brain extract by HPLC purification and characterized by mass spectrometry. This 26-aa neuropeptide, which belongs to the RFamide peptide family, was designated… Expand
Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions
- P. Simon, R. Dupuis, J. Costentin
- Psychology, Medicine
- Behavioural Brain Research
- 31 March 1994
When mice are introduced into an open-field, they are inclined to explore mainly the peripheral zone of this open-field. This tendency to remain close the walls, called thigmotaxis, decreases… Expand
The Endomorphin System and Its Evolving Neurophysiological Role
- J. Fichna, A. Janecka, J. Costentin, J. do Rego
- Biology, Medicine
- Pharmacological Reviews
- 1 March 2007
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are two endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid receptor. The… Expand
Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Food Intake in Mice Through Activation of the Hypothalamic Melanocortin System
- L. Mounien, J. D. Rego, +7 authors S. Jégou
- Biology, Medicine
- Neuropsychopharmacology
- 2009
Pituitary adenylate cyclase-activating polypeptide (PACAP) and the proopiomelanocortin (POMC)-derived peptide, α-melanocyte-stimulating hormone (α-MSH), exert anorexigenic activities. While α-MSH is… Expand
Nociceptin stimulates locomotion and exploratory behaviour in mice.
- S. Florin, C. Suaudeau, J. C. Meunier, J. Costentin
- Chemistry, Medicine
- European journal of pharmacology
- 12 December 1996
The recently characterized heptadecapeptide nociceptin, the endogenous agonist of the orphan opioid receptor-like 1 (ORL1 receptor), has been tested for its effects on locomotion and exploratory… Expand
Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice
- P. Simon, C. Hémet, C. Ramassamy, J. Costentin
- Psychology, Medicine
- European Neuropsychopharmacology
- 1 December 1995
Previously established dose-response curves indicated that modafinil 20-40 mg/kg i.p. elicited in mice an obvious stimulation of locomotor activity roughly similar to that induced by (+)amphetamine… Expand
Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.
- F. Sautel, N. Griffon, +7 authors A. Mann
- Biology, Medicine
- The Journal of pharmacology and experimental…
- 1 December 1995
Nafadotride (N[(n-butyl-2-pyrrolidinyl)methyl]-1-methoxy-4-cyano naphtalene-2-carboxamide) is a novel compound, which inhibits potently and stereoselectively [125I]iodosulpride binding at recombinant… Expand
The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes
- I. Dubuc, J. Costentin, +5 authors P. Kitabgi
- Biology, Medicine
- British journal of pharmacology
- 1 June 1994
The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently shown to inhibit NT binding to the cloned rat and human NT receptor and to antagonize NT effects in a variety of in vitro and in… Expand
Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin
- I. Dubuc, P. Sarret, +8 authors J. Mazella
- Chemistry, Medicine
- The Journal of Neuroscience
- 1 January 1999
The neuropeptide neurotensin (NT) elicits hypothermic and naloxone-insensitive analgesic responses after brain injection. Recent pharmacological evidence obtained with NT agonists and antagonists… Expand