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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
It was found that A2aR-knockout mice were viable and bred normally, and male mice were much more aggressive towards intruders, whereas caffeine, which normally stimulates exploratory behaviour, became a depressant of exploratory activity.
Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity
- N. Chartrel, C. Dujardin, H. Vaudry
- BiologyProceedings of the National Academy of Sciences…
- 1 December 2003
The conservation of the primary structure of 26 RFa during vertebrate evolution, the discrete localization of the mRNA encoding its precursor in hypothalamic nuclei involved in the control of feeding behavior, and the observation that 26RFa possesses orexigenic properties indicate that this neuropeptide may play important biological functions.
Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions
The Endomorphin System and Its Evolving Neurophysiological Role
- J. Fichna, A. Janecka, J. Costentin, J. Do Régo
- Biology, PsychologyPharmacological Reviews
- 1 March 2007
The relationship between these two μ-opioid receptor-selective peptides and endogenous neurohormones and neurotransmitters is described and the role of endomorphins from the physiological point of view is evaluated.
The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A2A receptors
- M. E. Yacoubi, C. Ledent, J. Ménard, M. Parmentier, J. Costentin, J. Vaugeois
- Biology, PsychologyBritish journal of pharmacology
- 1 April 2000
The results suggest that the stimulant effect of low doses of caffeine is mediated by A2A receptor blockade while the depressant effect seen at higher doses under some conditions is explained by A1 receptor blockade.
Pituitary Adenylate Cyclase-Activating Polypeptide Inhibits Food Intake in Mice Through Activation of the Hypothalamic Melanocortin System
Results indicate that PACAP, acting through PAC1-R, may inhibit food intake via a melanocortin-dependent pathway and suggest a central action of PACAP in the control of glucose metabolism.
Nociceptin stimulates locomotion and exploratory behaviour in mice.
The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A2A adenosine receptor antagonists
- M. E. Yacoubi, C. Ledent, M. Parmentier, J. Costentin, J. Vaugeois
- Biology, PsychologyPsychopharmacology
- 1 February 2000
Whether the anxiogenic effects of caffeine observed in mice depend on the blockade of A2A receptor or their long-term blockade after chronic ingestion of caffeine may be responsible for increase proneness to anxiety.