tyrosine 3-monooxygenase activity

Known as: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating), tyrosine hydroxylase activity, tyrosine 3-hydroxylase activity 
Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14… (More)

Topic mentions per year

Topic mentions per year

1966-2018
0204019662018

Papers overview

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Highly Cited
2005
Highly Cited
2005
Cannabinoids have been reported to provide neuroprotection in acute and chronic neurodegeneration. In this study, we examined… (More)
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Highly Cited
2002
Highly Cited
2002
The alpha-synuclein gene is implicated in the pathogenesis of Parkinson's disease. Although alpha-synuclein function is uncertain… (More)
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Highly Cited
2002
Highly Cited
2002
Methamphetamine (METH) selectively injures the neurites of dopamine (DA) neurons, generally without inducing cell death. It has… (More)
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Highly Cited
1998
Highly Cited
1998
The pathogenesis of Parkinson's disease is still poorly understood. To address the hypothesis that immune-mediated events, such… (More)
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Highly Cited
1995
Highly Cited
1995
Neurotoxic doses of methamphetamine (METH) can cause hyperthermia in experimental animals. Damage sustained to dopaminergic nerve… (More)
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1984
1984
Muscarinic agonists cause a stable activation of tyrosine 3-monooxygenase in the superior cervical ganglion and increase the… (More)
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1982
1982
The activity of tyrosine 3-monooxygenase in rat superior cervical ganglia in vitro was measured by monitoring their rate of dopa… (More)
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Highly Cited
1980
Highly Cited
1980
Tryptophan hydroxylase (TPH) activity was measured in various rat brain regions after administering large doses of… (More)
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Highly Cited
1977
Highly Cited
1977
Measurements on human brain samples of some enzymes concerned with neurotransmitter synthesis suggest serious losses with age… (More)
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Highly Cited
1975
Highly Cited
1975
Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d… (More)
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