FAQ

tyrosine 3-monooxygenase activity

Known as: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating), tyrosine hydroxylase activity, tyrosine 3-hydroxylase activity 
Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14… (More)

Topic mentions per year

Topic mentions per year

1966-2018
0204019662018

Related topics

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5 relations
TH geneTyrosine 3-Monooxygenasenegative regulation of tyrosine 3-monooxygenase activitypositive regulation of tyrosine 3-monooxygenase activity
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Related mentions per year

Related mentions per year

1964-2018
1960198020002020
tyrosine 3-monooxygenase activity
TH gene
Tyrosine 3-Monooxygenase
regulation of tyrosine 3-monooxygenase activity
negative regulation of tyrosine 3-monooxygenase activity
positive regulation of tyrosine 3-monooxygenase activity

Papers overview

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Highly Cited
2005
Highly Cited
2005
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.
Cannabinoids have been reported to provide neuroprotection in acute and chronic neurodegeneration. In this study, we examined… (More)
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Highly Cited
2002
Highly Cited
2002
A role for alpha-synuclein in the regulation of dopamine biosynthesis.
The alpha-synuclein gene is implicated in the pathogenesis of Parkinson's disease. Although alpha-synuclein function is uncertain… (More)
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Highly Cited
2002
Highly Cited
2002
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis.
Methamphetamine (METH) selectively injures the neurites of dopamine (DA) neurons, generally without inducing cell death. It has… (More)
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Highly Cited
1998
Highly Cited
1998
Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system.
The pathogenesis of Parkinson's disease is still poorly understood. To address the hypothesis that immune-mediated events, such… (More)
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Highly Cited
1995
Highly Cited
1995
Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents.
Neurotoxic doses of methamphetamine (METH) can cause hyperthermia in experimental animals. Damage sustained to dopaminergic nerve… (More)
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1984
1984
Muscarine increases tyrosine 3-monooxygenase activity and phospholipid metabolism in the superior cervical ganglion of the rat.
Muscarinic agonists cause a stable activation of tyrosine 3-monooxygenase in the superior cervical ganglion and increase the… (More)
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1982
1982
Both nicotinic and muscarinic agonists acutely increase tyrosine 3-monooxygenase activity in the superior cervical ganglion.
The activity of tyrosine 3-monooxygenase in rat superior cervical ganglia in vitro was measured by monitoring their rate of dopa… (More)
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Highly Cited
1980
Highly Cited
1980
Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain.
Tryptophan hydroxylase (TPH) activity was measured in various rat brain regions after administering large doses of… (More)
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Highly Cited
1977
Highly Cited
1977
Aging and extrapyramidal function.
Measurements on human brain samples of some enzymes concerned with neurotransmitter synthesis suggest serious losses with age… (More)
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Highly Cited
1975
Highly Cited
1975
The pharmacological and anatomical substrates of the amphetamine response in the rat.
Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d… (More)
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