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tyrosine 3-monooxygenase activity

Known as: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating), tyrosine hydroxylase activity, tyrosine 3-hydroxylase activity 
Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14… Expand
National Institutes of Health

Related topics

Related topics

4 relations
TH geneTyrosine 3-Monooxygenasenegative regulation of tyrosine 3-monooxygenase activitypositive regulation of tyrosine 3-monooxygenase activity

Papers overview

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Highly Cited
2005
Highly Cited
2005
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease
Cannabinoids have been reported to provide neuroprotection in acute and chronic neurodegeneration. In this study, we examined… Expand
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Review
2004
Review
2004
Tyrosine hydroxylase phosphorylation: regulation and consequences.
The rate-limiting enzyme in catecholamine synthesis is tyrosine hydroxylase. It is phosphorylated at serine (Ser) residues Ser8… Expand
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Highly Cited
2002
Highly Cited
2002
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis.
Methamphetamine (METH) selectively injures the neurites of dopamine (DA) neurons, generally without inducing cell death. It has… Expand
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Highly Cited
1998
Highly Cited
1998
Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system.
The pathogenesis of Parkinson's disease is still poorly understood. To address the hypothesis that immune-mediated events, such… Expand
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Highly Cited
1998
Highly Cited
1998
The effects of methamphetamine on the production of free radicals and oxidative stress.
The effects of methamphetamine (METH) on pro-oxidant processes and on the production of reactive oxygen species were examined in… Expand
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Review
1996
Review
1996
Intricate regulation of tyrosine hydroxylase activity and gene expression.
Tyrosine hydroxylase catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and… Expand
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Highly Cited
1995
Highly Cited
1995
7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and…
The effects of 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2 (1H)- quinolinone (OPC-14597), a derivative of… Expand
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Highly Cited
1991
Highly Cited
1991
Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
Ciliary neurotrophic factor (CNTF) is a potent survival molecule for a variety of embryonic neurons in culture. The developmental… Expand
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Highly Cited
1978
Highly Cited
1978
Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons.
Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine… Expand
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Highly Cited
1975
Highly Cited
1975
The pharmacological and anatomical substrates of the amphetamine response in the rat
Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d… Expand
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