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tyrosine 3-monooxygenase activity

Known as: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating), tyrosine hydroxylase activity, tyrosine 3-hydroxylase activity 
Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14… Expand
National Institutes of Health

Related topics

Related topics

4 relations
TH geneTyrosine 3-Monooxygenasenegative regulation of tyrosine 3-monooxygenase activitypositive regulation of tyrosine 3-monooxygenase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Tyrosine hydroxylase phosphorylation: regulation and consequences
The rate‐limiting enzyme in catecholamine synthesis is tyrosine hydroxylase. It is phosphorylated at serine (Ser) residues Ser8… Expand
Highly Cited
2002
Highly Cited
2002
A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis
The α-synuclein gene is implicated in the pathogenesis of Parkinson's disease. Although α-synuclein function is uncertain, the… Expand
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Review
1996
Review
1996
Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression
Abstract: Tyrosine hydroxylase catalyzes the rate‐limiting step in the biosynthesis of the catecholamines dopamine… Expand
Highly Cited
1991
Highly Cited
1991
Regional distribution, developmental changes, and cellular localization of CNTF-mRNA and protein in the rat brain
Ciliary neurotrophic factor (CNTF) is a potent survival molecule for a variety of embryonic neurons in culture. The developmental… Expand
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Highly Cited
1978
Highly Cited
1978
Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons.
Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine… Expand
Highly Cited
1978
Highly Cited
1978
Long-term changes in dopaminergic innervation of caudate nucleus after continuous amphetamine administration.
Silicone pellets containing d-amphetamine base were implanted subcutaneously in rats. These pellets release amphetamine… Expand
Highly Cited
1975
Highly Cited
1975
The pharmacological and anatomical substrates of the amphetamine response in the rat
Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d… Expand
Highly Cited
1972
Highly Cited
1972
Evidence for a receptor‐mediated feedback control of striatal tyrosine hydroxylase activity
WE have previously reported that cutting the nigrostriatal dopamine-carrying axons unexpectedly results in a transient increase… Expand
Highly Cited
1971
Highly Cited
1971
Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine
1 After intracisternal administration, 6‐hydroxydopamine had a greater effect on brain noradrenaline than on dopamine. 2… Expand
Highly Cited
1966
Highly Cited
1966
The tyrosine hydroxylase activity of mammalian tyrosinase.
  • S. Pomerantz
  • The Journal of biological chemistry
  • 1966
    • Corpus ID: 5294498
Abstract The tyrosine hydroxylase activity of tyrosinase from hamster melanoma has been studied by measurement of the release of… Expand
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