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tyrosine 3-monooxygenase activity

Known as: L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating), tyrosine hydroxylase activity, tyrosine 3-hydroxylase activity 
Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. [EC:1.14… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Cannabinoids have been reported to provide neuroprotection in acute and chronic neurodegeneration. In this study, we examined… Expand
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Review
2004
Review
2004
The rate-limiting enzyme in catecholamine synthesis is tyrosine hydroxylase. It is phosphorylated at serine (Ser) residues Ser8… Expand
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Highly Cited
2002
Highly Cited
2002
Methamphetamine (METH) selectively injures the neurites of dopamine (DA) neurons, generally without inducing cell death. It has… Expand
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Highly Cited
1998
Highly Cited
1998
The pathogenesis of Parkinson's disease is still poorly understood. To address the hypothesis that immune-mediated events, such… Expand
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Highly Cited
1998
Highly Cited
1998
The effects of methamphetamine (METH) on pro-oxidant processes and on the production of reactive oxygen species were examined in… Expand
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Review
1996
Review
1996
Tyrosine hydroxylase catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and… Expand
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Highly Cited
1995
Highly Cited
1995
The effects of 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2 (1H)- quinolinone (OPC-14597), a derivative of… Expand
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Highly Cited
1991
Highly Cited
1991
Ciliary neurotrophic factor (CNTF) is a potent survival molecule for a variety of embryonic neurons in culture. The developmental… Expand
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Highly Cited
1978
Highly Cited
1978
Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine… Expand
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Highly Cited
1975
Highly Cited
1975
Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d… Expand
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