J. Axelrod

Publications592
h-index133
Citations56,117
Highly Influential Citations518
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Enzymatic O-methylation of epinephrine and other catechols.
TLDR
The properties of an enzyme that transfers the methyl group of S-adenosylmethionine to the hydroxyl group in position 3 of epinephrine and other catechols are described. Expand
Stress hormones: their interaction and regulation.
TLDR
Together these agents appear to determine the complex physiologic responses to a variety of stressors. Expand
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.
TLDR
Anandamide appears to exhibit the essential criteria required to be classified as a cannabinoid/anandamide receptor agonist and shares similar nonreceptor effects on arachidonic acid and intracellular calcium release as other cannabinoid agonists. Expand
Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
TLDR
The distribution of anandamide in human brain and spleen supports its potential role as an endogenous agonist in central and peripheral tissues and suggests that it is metabolized in tissues where it is synthesized, and that its action is probably not hormonal in nature. Expand
Purification and properties of phenylethanolamine-N-methyl transferase.
  • J. Axelrod
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1 May 1962
TLDR
The assay, purification, properties, and distribution of an enzyme, phenylethanolamine-N-methyl transferase, that N-methylates the nitrogen of norepinephrine as well as that of a number of phenylethaolamine derivatives are described. Expand
A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain.
TLDR
The disappearance of H 3 -norepinephrine administered by the direct injection technique and its modification by drugs are similar to that of material introduced by stereotaxic procedures. Expand
Enzymatic O-Methylation of N-Acetylserotonin to Melatonin
An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This… Expand
Serum Dopamine‐Beta‐Hydroxylase Activity
TLDR
By using a sensitive new enzymatic assay, a dopamine-β-hydroxylase activity was found in the blood of both man and the rat and it is located in the serum and is not associated with the formed elements of blood. Expand
Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers
TLDR
GTP-binding (G) proteins transduce receptor-mediated signals for a variety of effector systems (adenylate cyclase, cyclic nucleotide phosphodiesterases, ion channels and phospholipase C) and another effector system that is linked to a G protein is described. Expand
Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents
TLDR
It is demonstrated that anandamide has biological and behavioral effects in awake rodents, some of which are similar to the reported actions of THC. Expand
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