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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.
Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely withExpand
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The pharmacological and anatomical substrates of the amphetamine response in the rat
Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion ofExpand
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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely withExpand
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Restricted eating with weight loss selectively decreases extracellular dopamine in the nucleus accumbens and alters dopamine response to amphetamine, morphine, and food intake
Weight loss is known to alter food intake and drug self-administration, but the neural basis of this is unknown. Therefore, we studied effects of weight loss on neurochemistry of a brain mechanismExpand
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Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity.
The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which areExpand
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Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain.
Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. ThisExpand
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Opiate receptor binding affected differentially by opiates and opioid peptides.
The potencies of various opiates in displacing several 3H-opiate ligands' binding to rat membranes vary depending on the nature of the ligand. Whereas opiate antagonists, as well as the opioidExpand
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Increased brain dopamine and dopamine receptors in schizophrenia.
In postmortem samples of caudate nucleus and nucleus accumbens from 48 schizophrenic patients, there were significant increases in both the maximum number of binding sites (Bmax) and the apparentExpand
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Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes.
[ 3 H]Haloperidol and [ 3 H]dopamine bind in saturable fashion to membranes from calf brain with high affinity and other characteristics indicating an association with post-synaptic dopamineExpand
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The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat
Rats trained to intravenously self-administer cocaine hydrochloride on a fixed ratio-5 schedule were subjected to a series of systemic injections of the D1 dopamine receptor selective antagonist SCHExpand
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