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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
TLDR
Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding, providing a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.
TLDR
Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding, providing a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
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Restricted eating with weight loss selectively decreases extracellular dopamine in the nucleus accumbens and alters dopamine response to amphetamine, morphine, and food intake
TLDR
Effects of weight loss on neurochemistry of a brain mechanism involved in behavior reinforcement and low extracellular dopamine levels in the nucleus accumbens of underweight rats suggest that low DA release in the NAC may be related to energy conservation during weight loss.
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The pharmacological and anatomical substrates of the amphetamine response in the rat
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Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine.
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Anterior pituitary dopamine receptors. Demonstration of interconvertible high and low affinity states of the D-2 dopamine receptor.
TLDR
The interactions of dopaminergic agonists and antagonists with binding sites in bovine anterior pituitary membranes have been investigated with radioligand-binding techniques and computer-modeling procedures and the binding data can be explained by postulating two states of the D-2 dopamine receptor.
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Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity.
The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are…
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Opiate receptor binding affected differentially by opiates and opioid peptides.
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3H-Spiroperidol labels dopamine receptors in pituitary and brain.
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The classification of dopamine receptors: relationship to radioligand binding.
TLDR
Since 1975, the elegantly simple radioligand binding technique has direct examination of the interactions of agonists and antagonists with putative dopamine receptors (DARs), and these studies form the major focus of this review.
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