trichostatin A

Known as: tricostatin, trichostatin, 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide 
A natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The inherited motor neuron disease spinal muscular atrophy (SMA) is caused by mutation of the telomeric survival motor neuron 1… (More)
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Highly Cited
2006
Highly Cited
2006
The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed to be associated with epigenetic… (More)
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Highly Cited
2001
Highly Cited
2001
Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE Trichostatin A (TSA), an antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture… (More)
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Review
2000
Review
2000
Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth arrest, differentiation, and/or apoptotic… (More)
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Highly Cited
1999
Highly Cited
1999
Densely methylated DNA associates with transcriptionally repressive chromatin characterized by the presence of underacetylated… (More)
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Highly Cited
1999
Highly Cited
1999
Mammalian DNA is methylated at many CpG dinucleotides. The biological consequences of methylation are mediated by a family of… (More)
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Highly Cited
1999
Highly Cited
1999
Histone deacetylases (HDACs) mediate changes in nucleosome conformation and are important in the regulation of gene expression… (More)
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Highly Cited
1998
Highly Cited
1998
Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically methylated in animal genomes. CpG… (More)
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Review
1995
Review
1995
Reversible acetylation at the epsilon-amino group of lysines located at the conserved domain of core histones is supposed to play… (More)
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