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trichostatin A

Known as: tricostatin, trichostatin, 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide 
A natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and… 
National Institutes of Health

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Antifungal AgentsHistone deacetylase inhibitorHydroxamic AcidsProtein Synthesis Inhibitors

Papers overview

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2010
2010
Sp proteins play a critical role in histone deacetylase inhibitor‐mediated derepression of CYP46A1 gene transcription
J. Neurochem. (2010) 113, 418–431. 
Highly Cited
2008
Highly Cited
2008
The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts.
Trichostatin A (TSA) is the most potent histone deacetylase (HDAC) inhibitor known. We previously reported that treatment of… 
Highly Cited
2006
Highly Cited
2006
Cardiac histones are substrates of histone deacetylase activity in hemorrhagic shock and resuscitation.
Highly Cited
2005
Highly Cited
2005
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and…
Interactions between histone deacetylase inhibitors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human… 
Highly Cited
2004
Highly Cited
2004
Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells
Although histone deacetylase (HDAC) inhibitors are emerging as a promising new treatment strategy in malignancy, how they exert… 
Highly Cited
2003
Highly Cited
2003
Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition
Highly Cited
2003
Highly Cited
2003
p15INK4b in HDAC inhibitor‐induced growth arrest
Highly Cited
2002
Highly Cited
2002
Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer.
Highly Cited
1998
Highly Cited
1998
Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate.
The reversible acetylation of histones by histone deacetylases (HDACs) and acetyltransferases (HATs) plays a fundamental role in… 
Highly Cited
1991
Highly Cited
1991
Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases.
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