Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function
- Minoru Yoshida, S. Horinouchi, T. Beppu
- Biology, ChemistryBioessays
- 1 May 1995
Trichostatin A and trapoxin are useful in analyzing the role of histone acetylation in chromatin structure and function as well as in determining the genes whose activities are regulated by histoneacetylation.
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.
- K. Nishi, M. Yoshida, D. Fujiwara, M. Nishikawa, S. Horinouchi, T. Beppu
- BiologyJournal of Biological Chemistry
- 4 March 1994
Enzymological characterization of EpoA, a laccase-like phenol oxidase produced by Streptomyces griseus.
- K. Endo, Y. Hayashi, T. Hibi, K. Hosono, T. Beppu, K. Ueda
- BiologyJournal of Biochemistry (Tokyo)
- 1 May 2003
EpoA-like activities were detected in cell extracts of 8/40 environmental actinomycetes strains, which suggests that similar oxidases are widely distributed among this group of bacteria.
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.
- K. Ueda, A. Yamashita, T. Beppu
- BiologyNucleic Acids Research
- 2004
The genomic information from S.thermophilum offers new insights into microbial diversity and evolutionary sciences, and provides a framework for characterizing the molecular basis underlying microbial commensalism.
Filimonas lacunae gen. nov., sp. nov., a member of the phylum Bacteroidetes isolated from fresh water.
- H. Shiratori, Y. Tagami, T. Morishita, Yuka Kamihara, T. Beppu, K. Ueda
- BiologyInternational Journal of Systematic and…
- 1 May 2009
On the basis of morphological features and phenotypic and phylogenetic data, strain YT21(T) represents a novel genus and species, for which the name Filimonas lacunae gen. nov., sp.
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.
- Y. Hoshikawa, H. Kwon, M. Yoshida, S. Horinouchi, T. Beppu
- Biology, ChemistryExperimental Cell Research
- 1 September 1994
Results suggest that gelsolin, an actin regulatory protein, is one of the putative proteins necessary for the morphological changes of human carcinoma cells induced by TSA.
A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp
- H. Ishizuka, S. Horinouchi, H. Kieser, D. Hopwood, T. Beppu
- BiologyJournal of Bacteriology
- 1 December 1992
An amino acid replacement from Asp to Glu at residue 52 of AfsQ1, generated by site-directed mutagenesis, resulted in loss of the protein's ability to stimulate antibiotic production in S. lividans.
Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor.
Ninety-five streptomycin-nonproducing mutants derived from Streptomyces griseus FT-1 by UV-irradiation could be classified into major two classes by cosynthesis tests and the production of A-factor was distributed among various species of actinomycetes.
Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase.
- A. Matsumoto, S. K. Hong, H. Ishizuka, S. Horinouchi, T. Beppu
- BiologyGene
- 1994
A signal transduction system similar to that found in higher organisms is involved in the regulation of secondary metabolism in the bacterial genus Streptomyces.
Autoregulatory factors and communication in actinomycetes.
- S. Horinouchi, T. Beppu
- BiologyAnnual Review of Microbiology
- 1992
The ability to produce a wide variety of secondary metabolites and a mycelial form of growth that develops into spores are two biological aspects characteristic of the gram-positive bacterial genus…
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