Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function
Trichostatin A and trapoxin are useful in analyzing the role of histone acetylation in chromatin structure and function as well as in determining the genes whose activities are regulated by histoneacetylation.
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.
Enzymological characterization of EpoA, a laccase-like phenol oxidase produced by Streptomyces griseus.
- K. Endo, Y. Hayashi, T. Hibi, K. Hosono, T. Beppu, K. Ueda
- BiologyJournal of Biochemistry (Tokyo)
- 1 May 2003
EpoA-like activities were detected in cell extracts of 8/40 environmental actinomycetes strains, which suggests that similar oxidases are widely distributed among this group of bacteria.
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.
The genomic information from S.thermophilum offers new insights into microbial diversity and evolutionary sciences, and provides a framework for characterizing the molecular basis underlying microbial commensalism.
Filimonas lacunae gen. nov., sp. nov., a member of the phylum Bacteroidetes isolated from fresh water.
- H. Shiratori, Y. Tagami, T. Morishita, Yuka Kamihara, T. Beppu, K. Ueda
- BiologyInternational Journal of Systematic and…
- 1 May 2009
On the basis of morphological features and phenotypic and phylogenetic data, strain YT21(T) represents a novel genus and species, for which the name Filimonas lacunae gen. nov., sp.
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.
- Y. Hoshikawa, H. Kwon, M. Yoshida, S. Horinouchi, T. Beppu
- Biology, ChemistryExperimental Cell Research
- 1 September 1994
Results suggest that gelsolin, an actin regulatory protein, is one of the putative proteins necessary for the morphological changes of human carcinoma cells induced by TSA.
A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp
- H. Ishizuka, S. Horinouchi, H. Kieser, D. Hopwood, T. Beppu
- BiologyJournal of Bacteriology
- 1 December 1992
An amino acid replacement from Asp to Glu at residue 52 of AfsQ1, generated by site-directed mutagenesis, resulted in loss of the protein's ability to stimulate antibiotic production in S. lividans.
Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor.
Ninety-five streptomycin-nonproducing mutants derived from Streptomyces griseus FT-1 by UV-irradiation could be classified into major two classes by cosynthesis tests and the production of A-factor was distributed among various species of actinomycetes.
Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase.
A signal transduction system similar to that found in higher organisms is involved in the regulation of secondary metabolism in the bacterial genus Streptomyces.
Autoregulatory factors and communication in actinomycetes.
The ability to produce a wide variety of secondary metabolites and a mycelial form of growth that develops into spores are two biological aspects characteristic of the gram-positive bacterial genus…