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Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.
TLDR
Results strongly suggest that LMB primarily inhibits the function of the crm1 gene which is required for maintaining higher order chromosome structures, correct gene expression, and cell growth in the fission yeast. Expand
Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function
TLDR
Trichostatin A and trapoxin are useful in analyzing the role of histone acetylation in chromatin structure and function as well as in determining the genes whose activities are regulated by histoneacetylation. Expand
Enzymological characterization of EpoA, a laccase-like phenol oxidase produced by Streptomyces griseus.
TLDR
EpoA-like activities were detected in cell extracts of 8/40 environmental actinomycetes strains, which suggests that similar oxidases are widely distributed among this group of bacteria. Expand
Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.
TLDR
The genomic information from S.thermophilum offers new insights into microbial diversity and evolutionary sciences, and provides a framework for characterizing the molecular basis underlying microbial commensalism. Expand
Filimonas lacunae gen. nov., sp. nov., a member of the phylum Bacteroidetes isolated from fresh water.
TLDR
On the basis of morphological features and phenotypic and phylogenetic data, strain YT21(T) represents a novel genus and species, for which the name Filimonas lacunae gen. nov., sp. Expand
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.
TLDR
Results suggest that gelsolin, an actin regulatory protein, is one of the putative proteins necessary for the morphological changes of human carcinoma cells induced by TSA. Expand
Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor.
TLDR
Ninety-five streptomycin-nonproducing mutants derived from Streptomyces griseus FT-1 by UV-irradiation could be classified into major two classes by cosynthesis tests and the production of A-factor was distributed among various species of actinomycetes. Expand
A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp.
TLDR
An amino acid replacement from Asp to Glu at residue 52 of AfsQ1, generated by site-directed mutagenesis, resulted in loss of the protein's ability to stimulate antibiotic production in S. lividans. Expand
Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase.
TLDR
A signal transduction system similar to that found in higher organisms is involved in the regulation of secondary metabolism in the bacterial genus Streptomyces. Expand
Codenitrification and denitrification are dual metabolic pathways through which dinitrogen evolves from nitrate in Streptomyces antibioticus.
TLDR
A unique system in an actinomycete that produces gaseous nitrogen (N( 2) and N(2)O) through both denitrification and codenitrification is demonstrated. Expand
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