Protein Synthesis Inhibitors

Known as: Protein Synthesis Antagonists, Antagonists, Protein Synthesis, Inhibitors, Protein Synthesis 
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes… (More)
National Institutes of Health

Related topics

Related topics

48 relations

Narrower (40)

2',5'-oligoadenylateAmino Acid Chloromethyl KetonesBrefeldin ACapreomycin
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Broader (3)

Enzyme InhibitorsProtein, Organized by FunctionProteins
In BloodPeptide Chain Elongation, Translationalaspects of radiation effectschemical synthesis
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Papers overview

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Highly Cited
2008
Highly Cited
2008
TNF-α Induces Two Distinct Caspase-8 Activation Pathways
The inflammatory response of mammalian cells to TNF-alpha can be switched to apoptosis either by cotreatment with a protein… (More)
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Highly Cited
2004
Highly Cited
2004
Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.
Extinction of conditioned fear is thought to form a long-term memory of safety, but the neural mechanisms are poorly understood… (More)
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Highly Cited
2004
Highly Cited
2004
Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time.
Recent accounts of memory suggest that retrieval of a learning experience transforms that memory into a labile state that… (More)
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Highly Cited
2001
Highly Cited
2001
Retrieval of memory for fear-motivated training initiates extinction requiring protein synthesis in the rat hippocampus.
Evidence that protein synthesis inhibitors induce amnesia in a variety of species and learning paradigms indicates that the… (More)
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Highly Cited
2000
Highly Cited
2000
Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala.
Previous studies have shown that long-term potentiation (LTP) can be induced in the lateral nucleus of the amygdala (LA) after… (More)
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Highly Cited
1998
Highly Cited
1998
Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA.
We have used a combined genetic and pharmacological approach to define the time course of the requirement for protein kinase A… (More)
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Highly Cited
1998
Highly Cited
1998
Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression.
BACKGROUND AND PURPOSE A short duration of ischemia (ie, ischemic preconditioning [PC]) can provide significant brain protection… (More)
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Highly Cited
1995
Highly Cited
1995
D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.
Agonists of the dopamine D1/D5 receptors that are positively coupled to adenylyl cyclase specifically induce a slowly developing… (More)
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Highly Cited
1993
Highly Cited
1993
Taste memory: the role of protein synthesis in gustatory cortex.
Application of the protein synthesis inhibitor anisomycin to the rat gustatory cortex before and during training impairs… (More)
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Highly Cited
1984
Highly Cited
1984
Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis.
Long-term potentiation (LTP) in the hippocampus has attracted attention as a model of neuronal plasticity in the central nervous… (More)
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