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Brefeldin A

Known as: Ascotoxin, 4H-Cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-, Synergisidin 
A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Trafficking through the Golgi apparatus requires members of the Arf family of GTPases, whose activation is regulated by guanine… Expand
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Review
2002
Review
2002
The fungal macrocyclic lactone brefeldin A (BFA) has proved to be of great value as an inhibitor of protein trafficking in the… Expand
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Highly Cited
2002
Highly Cited
2002
Brefeldin A (BFA) inhibits exocytosis but allows endocytosis, making it a valuable agent to identify molecules that recycle at… Expand
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Highly Cited
1999
Highly Cited
1999
We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway of budding yeast are the three… Expand
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Highly Cited
1992
Highly Cited
1992
THE fungal metabolite brefeldin A is a powerful tool for investigating membrane traffic in eukaryotic cells1. The effects of… Expand
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Highly Cited
1991
Highly Cited
1991
Addition of brefeldin A (BFA) to most cells results in both the formation of extensive, uncoated membrane tubules through which… Expand
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Highly Cited
1990
Highly Cited
1990
Characteristics of brefeldin A (BFA)-induced redistribution of Golgi proteins into the endoplasmic reticulum (ER) and its… Expand
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Highly Cited
1989
Highly Cited
1989
Abstract In cells treated with brefeldin A (BFA), movement of newly synthesized membrane proteins from the endoplasmic… Expand
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Highly Cited
1989
Highly Cited
1989
Brefeldin A (BFA) has been reported to block protein transport from the ER and cause disassembly of the Golgi complex. We have… Expand
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Highly Cited
1986
Highly Cited
1986
We examined the effect of brefeldin A, an antiviral antibiotic, on protein synthesis, intracellular processing, and secretion in… Expand
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