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Brefeldin A

Known as: Ascotoxin, 4H-Cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-, Synergisidin 
A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.
National Institutes of Health

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14 relations

Broader (6)

Anti-Bacterial AgentsAntibioticsAntifungal AgentsAntiviral Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

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Papers overview

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Highly Cited
2006
Highly Cited
2006
Dual Specificity of the Interfacial Inhibitor Brefeldin A for Arf Proteins and Sec7 Domains*
Guanine nucleotide exchange factors (GEFs), which activate small GTP-binding proteins (SMG) by stimulating their GDP/GTP exchange… 
Review
2005
Review
2005
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery.
Highly Cited
1999
Highly Cited
1999
Intracellular trafficking of dense granule proteins in Toxoplasma gondii and experimental evidences for a regulated exocytosis.
Highly Cited
1997
Highly Cited
1997
Dissociation of Coatomer from Membranes Is Required for Brefeldin A–induced Transfer of Golgi Enzymes to the Endoplasmic Reticulum
Addition of brefeldin A (BFA) to mammalian cells rapidly results in the removal of coatomer from membranes and subsequent… 
Review
1996
Review
1996
Brefeldin A effects in plant and fungal cells: something new about vesicle trafficking?
Whilst the function and organization of the secretory machinery in eukaryotic cells exhibit basic similarities, the… 
Highly Cited
1994
Highly Cited
1994
Stimulation of endogenous ADP-ribosylation by brefeldin A.
Brefeldin A (BFA) is a fungal metabolite that exerts profound and generally inhibitory actions on membrane transport. At least… 
Highly Cited
1991
Highly Cited
1991
Brefeldin A arrests the maturation and egress of herpes simplex virus particles during infection
Herpes simplex virus (HSV) requires the host cell secretory apparatus for transport and processing of membrane glycoproteins… 
Highly Cited
1991
Highly Cited
1991
Uncoupling of chondroitin sulfate glycosaminoglycan synthesis by brefeldin A
Brefeldin A has dramatic, well-documented, effects on the structural and functional organization of the Golgi complex. We have… 
Highly Cited
1990
Highly Cited
1990
Uncoupling of ganglioside biosynthesis by Brefeldin A.
We have studied the effect of Brefeldin A (BFA), an antiviral antibiotic, on glycosphingolipid metabolism in primary cultured… 
Highly Cited
1990
Highly Cited
1990
Use of brefeldin A to define sites of glycosphingolipid synthesis: GA2/GM2/GD2 synthase is trans to the brefeldin A block.
Brefeldin A (BFA) induces the rapid redistribution of the Golgi complex into the endoplasmic reticulum (ER), causing the… 
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