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Brefeldin A

Known as: Ascotoxin, 4H-Cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-decahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-, Synergisidin 
A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.
National Institutes of Health

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Anti-Bacterial AgentsAntibioticsAntifungal AgentsAntiviral Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

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Papers overview

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2004
2004
Anti-HeLa cell effect of cyanein
I have studied the s t ruc ture of the bur sa of Fabricius in the nestl ings of Dicrurus maerocercus V~ILLOT (King crow), Corvus… 
1998
1998
Short-term and long-term cytokine release by mouse bone marrow mast cells and the differentiated KU-812 cell line are inhibited by brefeldin A.
Mast cells and basophils produce a wide range of cytokines, including large amounts of both IL-6 and granulocyte-macrophage CSF… 
1997
1997
The effect of brefeldin A on terbutaline-induced sodium absorption in fetal rat distal lung epithelium
Abstract We studied the effect of brefeldin A, which inhibits the intracellular trafficking of membrane proteins from the… 
1996
1996
Brefeldin A inhibits the constitutive-like secretion of a sulfated protein in pancreatic acinar cells.
Sulfation is a common posttranslational modification of secretory proteins and serves as a valuable marker of constitutive and… 
1993
1993
Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines.
We have found that cerulenin, an antibiotic that inhibits de novo fatty acid and cholesterol biosynthesis and fatty acylation of… 
1992
1992
Inhibition of human cytomegalovirus maturation by brefeldin A.
Brefeldin A (BFA) was found to interfere with specific events of human cytomegalovirus (HCMV) maturation in human fibroblasts… 
Highly Cited
1991
Highly Cited
1991
Brefeldin A arrests the maturation and egress of herpes simplex virus particles during infection
Herpes simplex virus (HSV) requires the host cell secretory apparatus for transport and processing of membrane glycoproteins… 
1991
1991
Presentation of Leishmania donovani promastigotes occurs via a brefeldin A‐sensitive pathway
For the presentation of Leishmania promastigotes to polyclonal CD4+ T cells, a processing period within activated macrophages of… 
1969
1969
Effects of the macrolide antibiotic cyanein on HeLa cells growth and metabolism.
1966
1966
Effects of cyanein on growth and morphology of pathogenic fungi
Cyanein is an antibiotic isolated from Penicil l ium cyaneum (BETINA et al., 1962 b). I t has cytostatic (BETINX et al., 1962 a… 
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