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Essentials of Glycobiology
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycansExpand
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Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells1
Chronic inflammation is a complex process that promotes carcinogenesis and tumor progression; however, the mechanisms by which specific inflammatory mediators contribute to tumor growth remainExpand
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Thermus aquaticus gen. n. and sp. n., a nonsporulating extreme thermophile.
The isolation of a new thermophilic bacterium, Thermus aquaticus gen. n. and sp. n., is described. Successful enrichment requires incubation at 70 to 75 C, and the use of nutrient media relativelyExpand
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Symbol Nomenclature for Graphical Representations of Glycans.
Author(s): Varki, Ajit; Cummings, Richard D; Aebi, Markus; Packer, Nicole H; Seeberger, Peter H; Esko, Jeffrey D; Stanley, Pamela; Hart, Gerald; Darvill, Alan; Kinoshita, Taroh; Prestegard, James J;Expand
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Methods and Applications
TLDR
This thesis presents methods and applications for design for manufacturing using knowledge engineering, by using several approaches of knowledge engineering. Expand
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Lysosomal Protease Pathways to Apoptosis
We investigated the mechanism of lysosome-mediated cell death using purified recombinant pro-apoptotic proteins, and cell-free extracts from the human neuronal progenitor cell line NT2. PotentialExpand
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Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder
The congenital disorders of glycosylation (CDG) are characterized by defects in N-linked glycan biosynthesis that result from mutations in genes encoding proteins directly involved in theExpand
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RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
Patients with inflammatory bowel diseases are at increased risk for colorectal cancer, but the molecular mechanisms linking inflammation and cancer are not well defined. We earlier showed thatExpand
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Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer.
Inflammatory mediators play important roles in the development and progression of cancer. Cellular stress, damage, inflammation, and necrotic cell death cause release of endogenous damage-associatedExpand
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Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells.
Receptor tyrosine kinases (RTK) are therapeutic targets for the treatment of malignancy. However, tumor cells develop resistance to targeted therapies through the activation of parallel signalingExpand
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