Dual Specificity of the Interfacial Inhibitor Brefeldin A for Arf Proteins and Sec7 Domains*

@article{Zeeh2006DualSO,
  title={Dual Specificity of the Interfacial Inhibitor Brefeldin A for Arf Proteins and Sec7 Domains*},
  author={Jean-Christophe Zeeh and Mahel Zeghouf and C{\'e}dric Grauffel and Bernard Guibert and Elyette Martin and Annick Dejaegere and Jacqueline Cherfils},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={11805 - 11814}
}
Guanine nucleotide exchange factors (GEFs), which activate small GTP-binding proteins (SMG) by stimulating their GDP/GTP exchange, are emerging as candidate targets for the inhibition of cellular pathways involved in diseases. However, their specific inhibition by competitive inhibitors is challenging, because GEF and SMG families comprise highly similar members. Nature shows us an alternative strategy called interfacial inhibition, exemplified by Brefeldin A (BFA). BFA inhibits the activation… 
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TLDR
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