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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity
It is demonstrated that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic Rig-I signalling pathway to elicit host antiviral innate immunity.
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Role of the histone deacetylase complex in acute promyelocytic leukaemia
The findings suggest that oncogenic RARs mediate leukaemogenesis through aberrant chromatin acetylation, and that pharmacological manipulation of nuclear receptor co-factors may be a useful approach in the treatment of human disease.
Molecular cloning and characterization of human estrogen receptor βcx: A potential inhibitor of estrogen action in human
This study indicates that ERbetacx potentially inhibits ERalpha-mediated estrogen action and that alternative splicing of the C-terminal region and its inhibitory properties are characteristic of several members of nuclear receptor isoforms.
Association of bone mineral density with polymorphism of the estrogen receptor gene
- S. Kobayashi, S. Inoue, T. Hosoi, Y. Ouchi, M. Shiraki, H. Orimo
- Biology, MedicineJournal of bone and mineral research : the…
- 1 March 1996
It is suggested that some variation of the ER gene linked to these RFLPs is associated with low BMD and that this at least partly explains the cause of postmenopausal osteoporosis in Japanese women.
Interaction of phytoestrogens with estrogen receptors alpha and beta.
The estrogenic activities of soy isoflavones after digestion with enteric bacteria in competition binding assays with hER alpha or hER beta protein, and in a gene expression assay using a yeast system were investigated by the growth of MCF-7 breast cancer cells.
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production (vol 11, pg 63, 2010)
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.
The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro.
- S. Ogawa, S. Inoue, M. Muramatsu
- Biology, Computer ScienceBiochemical and biophysical research…
- 4 February 1998
This study indicates that ER alpha and ER beta can interact in vivo, cross-signaling each other.
Inhibitory effects of B cells on antitumor immunity.
These studies provide the first mechanistic basis for the concept that B-cell depletion could therapeutically enhance antitumor immune responses to certain tumors by decreasing IL-10 production from B cells.