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The effects of trichostatin A on mRNA expression of chromatin structure-, DNA methylation-, and development-related genes in cloned mouse blastocysts.
TSA treatment of mouse SCNT oocytes decreased the expression of chromatin structure- and DNA methylation-related genes, and increased the expressionof Sox2 and cMyc genes in blastocysts, indicating that both transcripts are TSA-responsive genes. Expand
Analysis of development-related gene expression in cloned bovine blastocysts with different developmental potential.
The high Bcl-2 and Glut-1 gene expression suggests that some embryonic cells with damaged DNA in fibroblast-derived blastocysts are not removed, and their descendants later manifest abnormal placenta or fetus formation. Expand
Comparative analysis of development‐related gene expression in mouse preimplantation embryos with different developmental potential
It is indicated that abnormal expression patterns of development‐related genes during preimplantation development correlate with the low potential of NT oocytes to develop into young. Expand
Generation of induced pluripotent stem cells from buffalo (Bubalus bubalis) fetal fibroblasts with buffalo defined factors.
Results indicate that BFFs can be reprogrammed into biPSCs by buffalo defined factors, and the generation efficiency ofBiPSCs can be increased by inhibition of p53 expression. Expand
Gene expression in individual bovine somatic cell cloned embryos at the 8-cell and blastocyst stages of preimplantation development.
The present study demonstrated that the expression profiles of the 13 genes examined in Day 9 NT blastocysts produced from two different types of donor cells with different incidences of neonatal abnormalities are largely indistinguishable. Expand
Comparative gene expression analysis of bovine nuclear-transferred embryos with different developmental potential by cDNA microarray and real-time PCR to determine genes that might reflect calf
The mRNA expression pattern of interferon (IFN)-tau, a trophectoderm-related gene, differed between IVF, CNT, and FNTEight-cell embryos; few or none of the IVF or CNT eight- cell embryos expressed IFN-tau mRNA, but all eight-cell FNT embryos expressedIFN- tau. Expand
Treatment of donor cells with trichostatin A improves in vitro development and reprogramming of buffalo (Bubalus bubalis) nucleus transfer embryos.
The results suggest that treatment of donor cells with TSA can facilitate their nucleus reprogramming by affecting the acetylated status of H4K8 and improving the in vitro development of buffalo SCNT embryos. Expand
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42
  • Y. Xu, Y. Qi, +9 authors P. Xu
  • Biology, Medicine
  • International journal of molecular sciences
  • 1 March 2017
The cellular mechanisms by which CDC42 was responsible for the higher proliferation of HuH-7 cells mediated by HBx and the IQ Motif Containing GTPase Activating Protein 1 (IQGAP1), the downstream mediator of the CDC42 pathway, might be involved in the carcinogenesis induced byHBx. Expand
Comparative studies on the mRNA expression of development-related genes in an individual mouse blastocyst with different developmental potential.
Down-regulation of Sox2 and Oct4 genes is considered to be a candidate marker for the low potential of NT embryos to develop into young. Expand
Comparative Proteomic Analysis of Buffalo Oocytes Matured in vitro Using iTRAQ Technique
This is the first proteomic report on buffalo oocytes from different maturation stages and developmental competent status and it revealed that the up-regulated proteins in competent MII oocytes were related to chromosome segregation, microtubule-based process, protein transport, oxidation reduction, ribosome, and oxidative phosphorylation, etc. Expand