thienopyrimidine

 
National Institutes of Health

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2011
2011
In an effort to discover Aurora kinase inhibitors, an HTS hit revealed an amide containing pyrrolopyrimidine compound… (More)
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Highly Cited
2009
Highly Cited
2009
The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable… (More)
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2009
2009
Two new series of potent and selective dual EGFR/ErbB-2 kinase inhibitors derived from novel thienopyrimidine cores have been… (More)
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2009
2009
Herein we describe the design and synthesis of a novel series of potent thienopyrimidine P2Y12 inhibitors and the negative impact… (More)
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2009
2009
The SAR and improvement in potency against Tie2 of novel thienopyrimidine and thiazolopyrimidine kinase inhibitors are reported… (More)
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2006
2006
Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a… (More)
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2005
2005
A series of novel thienopyrimidine-based receptor tyrosine kinase inhibitors has been discovered. Investigation of structure… (More)
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2004
2004
Novel classes of thienopyrimidines and thienopyridines have been identified as potent inhibitors of VEGFR-2 kinase. The synthesis… (More)
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2001
2001
The effects of a series of thienopyrimidine derivatives on the prevention of cartilage destruction in articular disease were… (More)
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1999
1999
We synthesized a series of thienopyrimidine derivatives and examined their cytotoxic effects on several cell lines. One of the… (More)
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