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Synthesis of new [1,3,4]thiadiazolo[3,2-a]thieno[2,3-d]pyrimidinone derivatives with antiinflammatory activity.
- M. Modica, M. Santagati, A. Santagati, V. Cutuli, N. Mangano, A. Caruso
- Chemistry, MedicineDie Pharmazie
- 1 July 2000
The effect of various substituents in the thiophene ring on the pharmacological activity of the compounds was investigated and new thiadiazolothienopyrimidinones were synthesized.
Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat
- G. Clementi, A. Caruso, V. Cutuli, E. Bernardis, A. Prato, M. Amico-Roxas
- Chemistry, MedicineExperientia
- 15 July 1996
The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined and pre-treatment with neostigmine and domperidone decreased the inhibitory effect of peripherally injectedAmylin, but no effect was observed when the peptide was centrally injected.
Protective effects of calcitonin gene-related peptide in different experimental models of gastric ulcers.
Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat.
- G. Cantarella, G. Martinez, +6 authors G. Clementi
- Biology, MedicineEuropean journal of pharmacology
- 22 August 2005
The results suggest that the inhibitory effect of adrenomedullin on the expression of HGF and COX-2 is mediated by CGRP receptors.
Grapefruit juice effects on the bioavailability of cyclosporin-A in rats.
- N. Mangano, V. Cutuli, A. Caruso, E. de Bernardis, M. Amico-Roxas
- Chemistry, MedicineEuropean review for medical and pharmacological…
It was demonstrated that rats may be suitable models for in vivo investigation of the interaction mechanism between grapefruit juice and cyclosporin-A in rats, and results confirm that grapefruit Juice may act as an inhibitor of drug metabolism altering the disposition of concomittantly administered CyP3A4 in rats.
Synthesis and pharmacological properties of pyrazolotriazolopyrimidine derivatives
Synthesis and Pharmacological Properties of Pyrazolotriazolopyrimidine Derivatives.
Synthesis and Pharmacological Activities of Novel 3‐(Isoxazol‐3‐yl)‐quinazolin‐4(3H)‐one Derivatives
Several new 3‐(isoxazol‐3‐yl)‐quinazolin‐4(3H)‐one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic…
Antiinflammatory activity of adrenomedullin in the acetic acid peritonitis in rats.
Gastroprotective effect of adrenomedullin administered subcutaneously in the rat