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Gangliosides antinociceptive effects in rodents.
It is suggested that gangliosides can reduce the exudative phenomena interfering with the membrane permeability of the nerve-endings breaking the vicious circle of the neurogenic mechanisms of plasma extravasation.
Synthesis of new [1,3,4]thiadiazolo[3,2-a]thieno[2,3-d]pyrimidinone derivatives with antiinflammatory activity.
The effect of various substituents in the thiophene ring on the pharmacological activity of the compounds was investigated and new thiadiazolothienopyrimidinones were synthesized.
The analgesic activity of calcitonin and the central serotonergic system.
Synthesis and pharmacological study of a series of 3(2H)-pyridazinones as analgesic and antiinflammatory agents.
The synthesis and the pharmacological evaluation of some 3(2H)-pyridazinone derivatives showed a higher analgesic activity than phenylbutazone, while being devoid of ulcerogenic action.
Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat
The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined and pre-treatment with neostigmine and domperidone decreased the inhibitory effect of peripherally injectedAmylin, but no effect was observed when the peptide was centrally injected.
Grapefruit juice effects on the bioavailability of cyclosporin-A in rats.
It was demonstrated that rats may be suitable models for in vivo investigation of the interaction mechanism between grapefruit juice and cyclosporin-A in rats, and results confirm that grapefruit Juice may act as an inhibitor of drug metabolism altering the disposition of concomittantly administered CyP3A4 in rats.