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Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
TLDR
Data suggest that inhibition of neuronal apoptosis underlies short latency protective effects of EPO after cerebral ischemia and other brain injuries, and the neurotrophic actions suggest there may be longer-latency effects as well.
Erythropoietin Selectively Attenuates Cytokine Production and Inflammation in Cerebral Ischemia by Targeting Neuronal Apoptosis
TLDR
It is shown that recombinant human EPO markedly reduces astrocyte activation and the recruitment of leukocytes and microglia into an infarction produced by middle cerebral artery occlusion in rats, suggesting that rhEPO attenuates ischemia-induced inflammation by reducing neuronal death rather than by direct effects upon EPO-R–expressing inflammatory cells.
Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
TLDR
It is demonstrated that helix B of EPO, which faces the aqueous medium when EPO is bound to the receptor homodimer, is both neuroprotective in vitro and tissue protective in vivo in a variety of models, including ischemic stroke, diabetes-induced retinal edema, and peripheral nerve trauma.
Carrier‐dependent and Ca2+‐dependent 5‐HT and dopamine release induced by (+)‐amphetamine, 3,4‐methylendioxy‐methamphetamine, p‐chloroamphetamine and (+)‐fenfluramine
TLDR
The results indicate that the release induced by these compounds is both ‘carrier‐mediated’ and Ca2+‐dependent (possibly exocytotic‐like), with the specific carrier allowing the amphetamines to enter the synaptosome.
Cocaine-Seeking Behavior in Response to Drug-Associated Stimuli in Rats: Involvement of D3 and D2 Dopamine Receptors*
TLDR
It is confirmed that the partial agonist at the D3 receptors, BP897, might be a useful medication, and a role of D2 receptors in cue-induced cocaine-seeking behavior is suggested, which also suggest a roles of low dosages reducing and high dosages increasing the impact of cocaine-associated stimuli on rats' behavior.
Tianeptine, a selective enhancer of serotonin uptake in rat brain
TLDR
The biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake.
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