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Therapeutic options for the 2019 novel coronavirus (2019-nCoV)
The potential for repurposing existing antiviral agents to treat 2019-nCoV infection (now known as COVID-19) is discussed, some of which are already moving into clinical trials.
HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells*
The findings indicate that the minimal IN molecule in human cells is a homotetramer, suggesting that at least an octamer of IN is required to accomplish coordinated integration of both retroviral long terminal repeats and that LEDGF is a cellular factor involved in this process.
LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells*
We have reported that human immunodeficiency virus type 1 (HIV-1) integrase (IN) forms a specific nuclear complex with human lens epithelium-derived growth factor/transcription co-activator p75…
Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy
The insight into the clinical spectrum of HHV-6 is still evolving and, apart from being recognized as a major pathogen in transplant recipients, its role in central nervous system disease has become increasingly apparent.
Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.
- J. Wijnholds, C. Mol, P. Borst
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 20 June 2000
It is speculated that MRP5 might play a role in some cases of unexplained resistance to thiopurines in acute lymphoblastic leukemia and/or to antiretroviral nucleoside analogs in HIV-infected patients.
Angiogenesis: regulators and clinical applications.
Approved Antiviral Drugs over the Past 50 Years
This paper presents for the first time a comprehensive overview of antiviral drugs approved over the past 50 years, shedding light on the development of effective antiviral treatments against current and emerging infectious diseases worldwide.
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.
Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus
- M. Baba, R. Snoeck, R. Pauwels, E. De Clercq
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 November 1988
Several sulfated polysaccharides proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus.