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spiroplatin

Known as: Cis-1,1-diamino-methylcyclohexane sulfato-platinum, Platinum, (1,1-cyclohexanedimethanamine-n,n')(sulfato(2-)-O,O')-, (sp-4-2)-, aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum (II) 
A synthetic derivative of cyclohexane sulfatoplatinum with antineoplastic properties. Spiroplatin induces DNA cross-links, thereby inhibiting DNA… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antineoplastic AgentsOrganoplatinum Compounds

Narrower (1)

TNO 6

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Coordination modes vs. antitumor activity: synthesis and antitumor activity of novel platinum(II) complexes of N-substituted amino dicarboxylic acids.
2004
2004
Protein binding of five platinum compounds
SummaryAmicon Centriflo CF50A cones and Amicon MPS-1 micropartition systems with YMT filters were compared for the preparation of… 
2003
2003
Premelting structure: Vibrational dynamics of liquid, undercooled liquid, glassy, and crystal states in methylcyclohexane and deuterated methylcyclohexane
We present the results of the Raman studies on vibrational dynamics and static properties of methylcyclohexane (MCH) and… 
1994
1994
Dynamic NMR Study of the Tautomerism of Bicyclic Oxalamidines: Kinetic HH/HD/DD Isotope and Solvent Effects
The tautomerism of oralamidine, which consists of an intramolecular degenerate double proton transfer between nitrogen atoms, has… 
1992
1992
Multicenter phase II study of spiroplatin.
Spiroplatin was investigated in a multicenter phase II study, during which the drug was given over 4 h. 64 Patients with nine… 
1989
1989
The mutagenic and carcinogenic properties of three second generation antitumour platinum compounds: a comparison with cisplatin.
1986
1986
Evaluation of platinol analogs using the M5076 murine sarcoma.
The M5076 sarcoma was used to evaluate the antitumor activities of several analogs of Platinol presently undergoing clinical… 
1985
1985
Animal models for evaluating the myelosuppressive effects of cancer chemotherapeutic agents.
An important objective of new anticancer drug discovery programs is identification of agents that are less myelosuppressive than… 
1985
1985
Analysis of antitumour [1,1-bis(aminomethyl)cyclohexane]platinum(II) complexes derived from spiroplatin by high-performance liquid chromatography with differential pulse amperometric detection.
1984
1984
Influence of hydrolysis products of aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum(II) on toxicity in rats.
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