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Pharmacokinetics of free and total platinum species after short-term infusion of cisplatin.
TLDR
The binding of platinum to both plasma and proteins and rbcs in vitro (using patients' own blood) was slow, biphasic, and irreversible.
Pharmacokinetics of carboplatin after i.v. administration.
TLDR
Pharmacokinetics of the cisplatin analog carboplatin were studied in ovarian cancer patients who received short-term iv infusions of 290-370 mg/m2 and found that the overall in vivo reactivity ofcarboplatin is ten times lower than that of cis Platin.
Interaction of cisplatin and carboplatin with sodium thiosulfate: reaction rates and protein binding.
TLDR
Values suggest that direct chemical interaction in the plasma compartment has limited therapeutic consequences, whereas the anti-toxic effect of thiosulfate might be explained by the rapid inactivation of cisplatin in the kidneys.
Comparative pharmacokinetics of cisplatin and three analogues in mice and humans.
TLDR
The results suggest that the AUCp/AUCm ratio of free platinum over the first part of the concentration versus time curve can possibly be used to predict the maximal tolerated dose of platinum analogues in humans, during the early stage of phase I studies.
Pharmacokinetics of diammine(l,l cyclobutanedi carboxylato) platinum(II) (carboplatin) after intravenous administration
TLDR
Pharmacokinetics of the cisplatin analog carboplatin were studied in ovarian cancer patients who received short-term iv infusions of 290-370 mg/m2 and found that the overall in vivo reactivity ofcarboplatin is ten times lower than that of cis Platin.
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