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Structural aspects of antioxidant activity of flavonoids.
Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in doxorubicin-induced cardiotoxicity, which is believed to be caused by theExpand
Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial.
The purpose of the study was to determine the effect of vitamin D supplementation on bone turnover and bone loss in elderly women. Three hundred forty-eight women, ages 70 yr and older, wereExpand
The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects.
Vitamin D deficiency is common in the elderly and may lead to secondary hyperparathyroidism, cortical bone loss, and hip fractures. The effect of vitamin D supplementation for 1 yr was studied in 72Expand
Vitamin D status and sex hormone binding globulin: Determinants of bone turnover and bone mineral density in elderly women
To examine the relation of the vitamin D status and the remaining estrogen activity with bone turnover and bone mineral density (BMD) in elderly women, BMD was measured at both hips using dual‐energyExpand
Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy.
Chemotherapy i.p. is increasingly being tested as a treatment modality for cancer limited to the peritoneal cavity. We have developed a rat tumor model in which penetration and distribution ofExpand
The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.
Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally relatedExpand
Determinants of vitamin D status in patients with hip fracture and in elderly control subjects.
The factors that influence vitamin D status were investigated in 125 patients with hip fracture and in 74 elderly control subjects. The serum concentrations of 25-hydroxyvitamin D [25(OH)D] variedExpand
A quantum chemical explanation of the antioxidant activity of flavonoids.
Flavonoids are a group of naturally occurring antioxidants, which over the past years have gained tremendous interest because of their possible therapeutic applicability. The mechanism of theirExpand
Pharmacokinetics of free and total platinum species after short-term infusion of cisplatin.
Pharmacokinetic studies were performed in ten patients who received short-term (4-15-min) infusions of cisplatin. Computerized nonlinear least-squares analysis (NLIN) and an adapted curve-strippingExpand
Flavonoids as scavengers of nitric oxide radical.
Flavonoids are a group of naturally occurring compounds used, e.g., in the treatment of vascular endothelial damage. They are known to be excellent scavengers of oxygen free radicals. Since theExpand