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Antitumor activity and toxicity of cisplatin analogs.
Cisplatin-induced emesis in the Ferret: a new animal model.
The ferret, a carnivore weighing about 1 kg, was evaluated for its potential use in testing drugs for emetic and antiemetic activity. An acute emetic response to apomorphine indicated that the ferretExpand
Effect of butorphanol and morphine on pulmonary mechanics, arterial blood pressure and venous plasma histamine in the anesthetized dog.
Butorphanol, levo-N-cyclobutylmethyl-3, 14beta-dihydroxy-morphinan, is a new agonist-antagonist type analgetic agent which is 4 times more potent than morphine in experimental animals. EquianalgeticExpand
Antiemetic activity of butorphanol against cisplatin-induced emesis in ferrets and dogs.
The analgesic agent butorphanol was evaluated for its ability to block cisplatin-induced emesis in ferrets and dogs. In ferrets, butorphanol (0.15, 0.3, or 0.45 mg/kg; expressed in terms of theExpand
Tallysomycin S10b: Experimental antitumor activity and toxicity
SummaryTallysomycin S10b (TLM S10b), a structural analog of bleomycin (BLM), was evaluated and compared with BLM for antitumor activity in several murine tumor systems and for toxic effects in miceExpand
The mouse as a model for predicting the myelosuppressive effects of anticancer drugs
SummaryWe evaluated 17 clinically used anticancer drugs for their effects on total WBC and absolute neutrophil counts in BDF1 mice. These drugs were selected from three categories, based on theirExpand
Effects of tiodazosin, praxosin, trimazosin and phentolamine on blood pressure, heart rate and on pre- and postsynaptic alpha-adrenergic receptors in the rat.
Subcutaneous administration of tiodazosin (0.1-3 mg/kg), prazosin (0.01-1 mg/kg), trimazosin (10-30 mg/kg) and phentolamine (0.1-3 mg/kg) to conscious spontaneously hypertensive rats (SHR) producedExpand
Preclinical antitumor and toxicologic profile of carboplatin.
Carboplatin, an analog of the antitumor drug Platinol, was selected for clinical evaluation on the basis of its experimental antitumor and toxicologic profile in animal models. Described in thisExpand
BL-5255. I. Activity in animal models of immediate hypersensitivity reactions.
BL-5255 exhibited potent activity in several models of antigen-induced immediate hypersensitivity reactions in rats and guinea pigs. The compound was effective whether administered by oral orExpand
Toxicology screening in small animals.