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The antitumor agents
Mitomycin C: a review.
Summary Preclinical 1. Mitomycin C is an alkylating agent requiring reduction of the quinone to be active. 2. The aziridine ring is essential for the antitumor activity of mitomycin C. 3. The degreeExpand
Production and biological activity of rebeccamycin, a novel antitumor agent.
An actinomycete, strain C-38,383, was selected in a screening program for the isolation of novel antitumor agents. A yellow crystalline product, named rebeccamycin, was isolated from the mycelium andExpand
Antitumor activity and toxicity of cisplatin analogs.
Mitomycin C: a clinical update.
Mitomycin C was reviewed in this journal 25 years ago and an update of its clinical usefulness is appropriate. The current review is based on representative publications covering clinical trialsExpand
Cisplatin-induced emesis in the Ferret: a new animal model.
The ferret, a carnivore weighing about 1 kg, was evaluated for its potential use in testing drugs for emetic and antiemetic activity. An acute emetic response to apomorphine indicated that the ferretExpand
Isolation of lavendamycin, a new antibiotic from Streptomyces lavendulae.
The isolation of lavendamycin (1) an antibiotic closely related to streptonigrin (2) is described. Details of the taxonomic description ofS. lavendulae(strain C-22, 030), production of lavendamycin,Expand
Antiemetic activity of butorphanol against cisplatin-induced emesis in ferrets and dogs.
The analgesic agent butorphanol was evaluated for its ability to block cisplatin-induced emesis in ferrets and dogs. In ferrets, butorphanol (0.15, 0.3, or 0.45 mg/kg; expressed in terms of theExpand
Bleomycin, a review.
Inhibition of anaerobic bacteria as a screen for antitumor agents.
1. Various compounds of theoretical and practical interest in cancer research were tested for their ability to inhibit ten species of anaerobic bacteria. 2. The results obtained with at least oneExpand