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Mitomycin C: a review.
Mitomycin C: a clinical update.
  • W. T. Bradner
  • Medicine, Biology
    Cancer treatment reviews
  • 1 February 2001
It is concluded that mitomycin C has a definite place in the treatment of localized bladder cancer, is active, but needs to be redefined, in the context of newer regimens for breast, head and neck, and non-small cell lung cancers, and is active in, but is being displaced by, other drugs in cervical, gastric and pancreatic cancers.
Production and biological activity of rebeccamycin, a novel antitumor agent.
An actinomycete, strain C-38,383, was selected in a screening program for the isolation of novel antitumor agents. A yellow crystalline product, named rebeccamycin, was isolated from the mycelium and
Cisplatin-induced emesis in the Ferret: a new animal model.
The ferret was evaluated for its potential use in testing drugs for emetic and antiemetic activity and an acute emetic response to apomorphine indicated that the ferret can respond to emetic stimuli and suggested that it has an emetic chemoreceptor trigger zone.
Isolation of lavendamycin, a new antibiotic from Streptomyces lavendulae.
The isolation of lavendamycin an antibiotic closely related to streptonigrin is described, and its isolation and the biological activity are given.
Bleomycin, a review.
Antiemetic activity of butorphanol against cisplatin-induced emesis in ferrets and dogs.
The results of these studies suggest that butorphanol may be useful clinically in mitigating the emetic effects of cisplatin, indicating the involvement of opiate receptors.
Inhibition of anaerobic bacteria as a screen for antitumor agents.
The results seen with special classes of compounds suggest that some of the anaerobes may prove to be independently useful in the examination of these materials for inhibitory properties.