• Publications
  • Influence
The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.
TLDR
It is concluded that MRP is a plasma membrane drug-efflux pump that confers drug resistance in human lung carcinoma cells by generating a subline stably transfected with an expression vector containing MRP cDNA.
The drug resistance-related protein LRP is the human major vault protein
TLDR
The cloning and chromosome localization of the gene coding for the LRP protein is described and the deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein.
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
TLDR
This report provides a mechanistic basis for resistance to polyglutamatable antifolates through an MRP-mediated drug extrusion.
Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity.
TLDR
Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
TLDR
To anticipate possible long-term toxicities of angiogenesis inhibitors, understanding the molecular mechanisms involved in the toxicity should allow more specific and more potent inhibitors to be developed.
Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial.
TLDR
Intratumoral injection of JX-594 into primary or metastatic liver tumours was generally well-tolerated, and the maximum-tolerance dose (MTD) and safety of Jx-594 treatment was generallyWell-Tolerated.
Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma
TLDR
The prognostic value of HIF‐1α expression and its correlation with various clinicopathologic variables in patients with invasive breast carcinoma were investigated.
MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.
TLDR
These findings demonstrate the unique suitability of MUTZ-3 cells as an unlimited source of CD34+ DC progenitors for the study of cytokine-induced DC differentiation.
5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.
TLDR
5-FU is incorporated at detectable levels into RNA and DNA of human tumor tissue, but no relation between the efficacy of 5-FU treatment and incorporation was found, in contrast to TS.
Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer.
TLDR
The preliminary results of this phase II study suggest that coexpression of P-gp/p53 and a high level of staining for Ki-67 after chemotherapy are associated with a worse prognosis, and that prolonged neoadjuvant chemotherapy and the attainment of a pathological complete remission are important factors in determining outcome for patients with this disease.
...
1
2
3
4
5
...