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spiraprilat

Known as: 1,4-dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-carboxy-3-phenylpropyl)amino)-1-oxopropyl)-, (8S- (7(R*(R*)),8R*))-, spiraprilate 
 
National Institutes of Health

Papers overview

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2004
2004
SummaryThe pharmacokinetics and haemodynamic effects of orally administered spirapril, a novel angiotensinconverting enzyme (ACE… Expand
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2003
2003
A specific, sensitive and precise method for the simultaneous determination of spirapril (CAS 94841-17-5) and spiraprilat (CAS… Expand
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1994
1994
Spirapril is a prodrug that is converted by esterolysis to the active (but poorly absorbed) diacid spiraprilat. After intravenous… Expand
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1994
1994
The pharmacokinetics of spirapril and its active diacid metabolite spiraprilat were characterized in four groups of patients… Expand
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1994
1994
PATIENTS AND METHOD Spirapril is a recent ACE inhibitor with a both renal and hepatic elimination pathway. In order to determine… Expand
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1993
1993
Spiraprilat, a new angiotensin-converting enzyme (ACE) inhibitor, was compared with enalaprilat for its ability to improve left… Expand
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1992
1992
Radioimmunoassays for a nonsulfhydryl angiotensin converting enzyme inhibitor prodrug--spirapril--and its active metabolite… Expand
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1991
1991
The acute hemodynamic, hormonal, and pharmacokinetic responses to the oral angiotensin-converting enzyme (ACE) inhibitor… Expand
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1990
1990
The cardiac and hemodynamic effects of 3 doses (0.1, 0.3 and 1 mg/kg, iv) of spiraprilat, the diacid active metabolite of the new… Expand
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1989
1989
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… Expand
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