Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

spiraprilat

Known as: 1,4-dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-carboxy-3-phenylpropyl)amino)-1-oxopropyl)-, (8S- (7(R*(R*)),8R*))-, spiraprilate 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
SummaryThe pharmacokinetics and haemodynamic effects of orally administered spirapril, a novel angiotensinconverting enzyme (ACE… Expand
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 3
1997
1997
The aim of this study was to investigate the relations between the plasma concentrations of spiraprilat (the active metabolite of… Expand
1994
1994
PATIENTS AND METHOD Spirapril is a recent ACE inhibitor with a both renal and hepatic elimination pathway. In order to determine… Expand
1994
1994
Spirapril is a prodrug that is converted by esterolysis to the active (but poorly absorbed) diacid spiraprilat. After intravenous… Expand
1994
1994
The pharmacokinetics of spirapril and its active diacid metabolite spiraprilat were characterized in four groups of patients… Expand
1993
1993
Summary Spiraprilat, a new angiotensin-converting enzyme (ACE) inhibitor, was compared with enalaprilat for its ability to… Expand
1992
1992
Radioimmunoassays for a nonsulfhydryl angiotensin converting enzyme inhibitor prodrug–spirapril–and its active metabolite… Expand
1991
1991
Summary: The acute hemodynamic, hormonal, and pharmacokinetic responses to the oral angiotensin-converting enzyme (ACE) inhibitor… Expand
1990
1990
Summary— The cardiac and hemodynamic effects of 3 doses (0.1, 0.3 and 1 mg/kg, iv) of spiraprilat, the diacid active metabolite… Expand
1989
1989
The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is… Expand