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spiraprilat

Known as: 1,4-dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-carboxy-3-phenylpropyl)amino)-1-oxopropyl)-, (8S- (7(R*(R*)),8R*))-, spiraprilate 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Enalapril

Narrower (1)

SCH 33861
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Pharmacokinetics and haemodynamic effects of a single oral dose of the novel ACE inhibitor spirapril in patients with chronic liver disease
SummaryThe pharmacokinetics and haemodynamic effects of orally administered spirapril, a novel angiotensinconverting enzyme (ACE… 
2003
2003
Simultaneous Determination of Spirapril and Spiraprilat in Plasma by Capillary Gas Chromatography-Mass Spectrometry
Summary A specific, sensitive and precise method for the simultaneous determination of spirapril (CAS 94841-17-5) and spiraprilat… 
2003
2003
Drug Interaction of Spirapril Hydrochloride Monohydrate and Hydrochlorothiazide
Summary The potential influence of concomitantly administered hydrochlorothiazide (CAS 58-93-5) on the pharmacokinetics of… 
1997
1997
Pharmacokinetic-pharmacodynamic model relating spiraprilat plasma concentrations to systemic and regional hemodynamic effects in congestive heart failure.
The aim of this study was to investigate the relations between the plasma concentrations of spiraprilat (the active metabolite of… 
1995
1995
Spirapril
SynopsisSpirapril is a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor pro-drug which is converted to the active… 
1994
1994
Spirapril: pharmacokinetic properties and drug interactions.
Spirapril is a prodrug that is converted by esterolysis to the active (but poorly absorbed) diacid spiraprilat. After intravenous… 
1994
1994
[Kidney function in hypertensive patients with chronic renal failure treated with the dual eliminated ACE-inhibitor spirapril].
PATIENTS AND METHOD Spirapril is a recent ACE inhibitor with a both renal and hepatic elimination pathway. In order to determine… 
1993
1993
Effects of Spiraprilat, an Angiotensin‐Converting Enzyme Inhibitor, on Anesthetized Dogs in a New Model of Acute Left Ventricular Failure
Summary Spiraprilat, a new angiotensin-converting enzyme (ACE) inhibitor, was compared with enalaprilat for its ability to… 
1992
1992
Radioimmunoassays for Spirapril and Its Active Metabolite Spiraprilate: Performance and Application
Radioimmunoassays for a nonsulfhydryl angiotensin converting enzyme inhibitor prodrug–spirapril–and its active metabolite… 
1990
1990
Hemodynamic and cardiac effects of spiraprilat in normal and sodium depleted conscious dogs
Summary— The cardiac and hemodynamic effects of 3 doses (0.1, 0.3 and 1 mg/kg, iv) of spiraprilat, the diacid active metabolite… 
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