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Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo.
TLDR
No, but not prostacyclin, is essential for flow-mediated dilatation of large human arteries, and this response can be used as a test for the L-arginine/NO pathway in clinical studies.
Crucial Role of NO and Endothelium-Derived Hyperpolarizing Factor in Human Sustained Conduit Artery Flow-Mediated Dilatation
TLDR
It is demonstrated that NO and a cytochrome-related EDHF are involved in peripheral conduit artery flow-mediated dilatation in humans during sustained flow conditions and the synergistic effects of the inhibitors strongly suggest a functional interaction between NO and EDHF pathways.
Role of endogenous endothelin in chronic heart failure: effect of long-term treatment with an endothelin antagonist on survival, hemodynamics, and cardiac remodeling.
TLDR
Long-term treatment with an ET antagonist markedly increases survival in this rat model of CHF, and this increase in survival is associated with decreases in both preload and afterload and an increase in cardiac output as well as decreased LV hypertrophy, LV dilatation, and cardiac fibrosis.
Long-Term Heart Rate Reduction Induced by the Selective If Current Inhibitor Ivabradine Improves Left Ventricular Function and Intrinsic Myocardial Structure in Congestive Heart Failure
TLDR
In rats with CHF, long-term HRR induced by the selective If inhibitor ivabradine improves LV function and increases stroke volume, preserving cardiac output despite the HRR.
Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction
TLDR
Cardiac lymphatic structure and function in rats with MI are investigated and it is shown that, despite the endogenous cardiac lymphangiogenic response post-MI, the remodeling and dysfunction of collecting ducts contribute to the development of chronic myocardial edema and inflammation-aggravating cardiac fibrosis and dysfunction.
In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats.
TLDR
It is demonstrated that inhibition of NO synthesis unmasks a tonic pressor influence of endothelin, suggesting that this peptide could play a major role in pathophysiological situations associated with an impaired formation of NO.
Tendinous disorders attributed to statins: a study on ninety-six spontaneous reports in the period 1990-2005 and review of the literature.
TLDR
It is suggested that prescribers should be aware of tendinous complications related to statins, particularly in risky situations, including physical exertion and association with medications known to increase the toxicity of statins.
Exercise improves flow-mediated vasodilatation of skeletal muscle arteries in rats with chronic heart failure. Role of nitric oxide, prostanoids, and oxidant stress.
TLDR
Exercise partially restores flow-mediated dilatation of the peripheral arteries by increasing expression of endothelial nitric oxide synthase and preventing the production of vasoconstrictor prostanoids and free radicals and might contribute to the increase in exercise capacity after physical exercise in CHF.
Tissue Doppler Imaging Differentiates Physiological From Pathological Pressure-Overload Left Ventricular Hypertrophy in Rats
TLDR
Myocardial contraction and relaxation assessed by TDI were impaired in pressure-overload LVH but not in exercise LVH, therefore, TDI is more sensitive than conventional echocardiography for assessing myocardial dysfunction in Pressure-over load LVH and for predicting early recovery in myocardIAL function after loading conditions normalization.
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