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Drug-Related Problems in Hospitals
TLDR
Analysis of original publications published between 1990 and 2005 on the topics of medication errors and/or adverse drug events in hospitalised patients, focusing on the frequency of, risk factors for and avoidance of such problems associated with pharmacotherapy, indicated that medication errors occurred in a mean of 5.7% of all episodes of drug administration, but with a high variability among the 35 studies retrieved. Expand
Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier
TLDR
This in vitro study indicates that expression levels and activity of BCRP, and P-gp at the BBB may be altered by acute inflammation, possibly affecting the penetration of their substrates into the brain. Expand
The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies
TLDR
The results of this study demonstrate the usefulness of the hCMEC/D3 cell line as an in vitro model to study drug transport at the level of the human blood‐brain barrier. Expand
Dose Adjustment in Patients with Liver Disease
TLDR
In cirrhotic patients, creatinine clearance should be measured or estimated to gain a guideline for the dosing of drugs with predominant renal elimination and the clinical monitoring of pharmacological effects and toxicity of such drugs is important. Expand
Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia
TLDR
Lactic acidosis during current use of oral antidiabetes drugs was very rare and was associated with concurrent comorbidity. Expand
Interaction between grapefruit juice and midazolam in humans
TLDR
To investigate the effects of grapefruit juice on the pharmacokinetics and dynamics of midazolam, a new grapefruit-based formulation of the drug is developed. Expand
Fulminant liver failure in association with the emetic toxin of Bacillus cereus.
TLDR
Fulminant liver failure developed after the ingestion of food contaminated with the B. cereus emetic toxin, indicating that it caused liver failure in this patient. Expand
Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer
TLDR
A decreased risk of breast cancer was observed in female patients with type 2 diabetes using metformin on a long-term basis, and neither short-term met formin use nor use of sulfonylureas or other antidiabetes drugs was associated with a materially altered risk for breast cancer. Expand
Development and characterization of an animal model of carnitine deficiency.
TLDR
THP inhibits butyrobetaine hydroxylase competitively, blocks carnitine biosynthesis in vivo and interacts competitively with renal carnitin reabsorption, and can therefore serve as an animal model for human carnitines deficiency. Expand
Allogeneic hematopoietic SCT as treatment option for patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a consensus conference proposal for a standardized approach
TLDR
Standardization of the transplant protocol and the clinical and biochemical assessments will allow evaluation of the safety and efficacy of HSCT as well as optimization of therapy for patients with MNGIE. Expand
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