Drug-Related Problems in Hospitals
- A. Krähenbühl-Melcher, R. Schlienger, M. Lampert, M. Haschke, J. Drewe, S. Krähenbühl
- MedicineDrug Safety
Analysis of original publications published between 1990 and 2005 on the topics of medication errors and/or adverse drug events in hospitalised patients, focusing on the frequency of, risk factors for and avoidance of such problems associated with pharmacotherapy, indicated that medication errors occurred in a mean of 5.7% of all episodes of drug administration, but with a high variability among the 35 studies retrieved.
Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier
- B. Poller, J. Drewe, S. Krähenbühl, J. Huwyler, H. Gutmann
- BiologyCellular and molecular neurobiology
This in vitro study indicates that expression levels and activity of BCRP, and P-gp at the BBB may be altered by acute inflammation, possibly affecting the penetration of their substrates into the brain.
The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies
The results of this study demonstrate the usefulness of the hCMEC/D3 cell line as an in vitro model to study drug transport at the level of the human blood‐brain barrier.
Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer
A decreased risk of breast cancer was observed in female patients with type 2 diabetes using metformin on a long-term basis, and neither short-term met formin use nor use of sulfonylureas or other antidiabetes drugs was associated with a materially altered risk for breast cancer.
Interaction between grapefruit juice and midazolam in humans
Fulminant liver failure in association with the emetic toxin of Bacillus cereus.
Fulminant liver failure developed after the ingestion of food contaminated with the B. cereus emetic toxin, indicating that it caused liver failure in this patient.
Dose Adjustment in Patients with Liver Disease
In cirrhotic patients, creatinine clearance should be measured or estimated to gain a guideline for the dosing of drugs with predominant renal elimination and the clinical monitoring of pharmacological effects and toxicity of such drugs is important.
Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia
Lactic acidosis during current use of oral antidiabetes drugs was very rare and was associated with concurrent comorbidity.
Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects
A first-in-man study to determine pharmacokinetics, pharmacodynamics, safety, and tolerability of recombinant ACE2 in healthy volunteers found it well tolerated by healthy human subjects.