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Opportunities to Optimize Tacrolimus Therapy in Solid Organ Transplantation: Report of the European Consensus Conference
TLDR
The importance of obtaining multicenter prospective trials to assess the efficacy of alternative strategies to TAC trough concentrations is emphasized, and single time points, limited sampling strategies, and area under concentration-time curve have all been considered to determine the most appropriate sampling procedure that correlates with efficacy. Expand
Therapeutic Drug Monitoring of Mycophenolate Mofetil in Transplantation
TLDR
A roundtable meeting to discuss the use of therapeutic drug monitoring (TDM) to guide immunosuppression with mycophenolate mofetil was held in New York in December 2004, and it was agreed that TDM might help optimize outcomes, especially in patients at higher risk of rejection. Expand
Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation.
TLDR
The goal of this consensus meeting was to offer information to transplant practitioners on clinically relevant pharmacokinetic characteristics of MPA, to rationalize the basis for currently advised target exposure ranges for MPA in various types of organ transplantation, and to summarize available methods for application of M PA TDM in clinical practice. Expand
Current Issues in Therapeutic Drug Monitoring of Mycophenolic Acid: Report of a Roundtable Discussion
TLDR
The final document is intended as an introduction to the topic of TDM of MPA and provides a summary of what was discussed at the Nice meeting, and includes recommendations for TDM strategies based on the current pharmacokinetic and pharmacodynamic data for MPA. Expand
The Influence of Pharmacogenetics on the Time to Achieve Target Tacrolimus Concentrations after Kidney Transplantation
TLDR
An initial dosing regimen for tacrolimus based on knowledge of the CYP3AP1 genotype and subsequently guided by concentration measurements has the potential to increase the proportion of patients achieving target blood concentrations early after transplantation. Expand
Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and p-glycoprotein correlate with dose requirement
TLDR
The CYP3AP1 genotype is a major factor in determining the dose requirement for tacrolimus, and genotyping may be of value in planning patient-specific drug dosing. Expand
Plasma Concentrations of Inflammatory Cytokines Rise Rapidly during ECMO-related SIRS due to the Release of Pre-formed Stores in the Intestine
TLDR
Porcine neonatal porcine ECMO was associated with systemic inflammatory changes similar to those seen in human neonates, and Mobilization of preformed cellular stores of inflammatory cytokines such as in mucosal mast cells may have an important pathophysiological role in ECMO-related SIRS. Expand
Therapeutic drug monitoring of immunosuppressant drugs.
TLDR
The purpose of this review is to examine the current strategies in use for the therapeutic drug monitoring of immunosuppressant drugs and to discuss some of the factors that impinge on the monitoring of these drugs. Expand
Side Effects of Long-term Amiodarone Therapy
TLDR
Important effects were seen particularly in the thyroid gland, liver, lung and skin, and corneal microdeposits were always found when sought, but did not cause impairment of visual acuity. Expand
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