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Valproic acid overdose and L-carnitine therapy.
- H. Ishikura, N. Matsuo, M. Matsubara, T. Ishihara, N. Takeyama, T. Tanaka
- Journal of analytical toxicology
It is suggested that enhanced drug excretion and L-carnitine supplementation may prevent potentially fatal hepatic dysfunction after VPA overdose and the patient recovered completely and was discharged on the eighth hospital day without any sequelae. Expand
Effects of Spiraprilat, an Angiotensin‐Converting Enzyme Inhibitor, on Anesthetized Dogs in a New Model of Acute Left Ventricular Failure
- M. Nakazawa, T. Ishihara, Y. Takahashi, M. Okuhira, S. Imai
- Journal of cardiovascular pharmacology
- 1 October 1993
Data indicate that the beneficial effects of both inhibitors extended not only to LV function but also to myocardial energy metabolism in ALVF, and hemodynamic changes indicated establishment of stable ALFF of a moderate degree. Expand
Effects of 16,16-dimethyl prostaglandin E2 on surface epithelial cell damage in the rat stomach induced by vagal nerve stimulation.
VS-induced SEC damage was caused by increased gastric contractions and not by increased Gastric acid secretion, and dmPGE2 protects against SEC damage by inhibiting gastriccontractions. Expand
Gastric mucosal protection induced by restraint and water-immersion stress in rats.
It is found that adaptive protection can be achieved by restraint and water-immersion stress and the protective effect of stress was markedly decreased by subdiaphragmatic truncal vagotomy, and electrical stimulation of vagal nerves afforded similar protection as observed after stress. Expand
Hyperammonemia reduces water immersion--restraint stress gastric ulcers in rats.
- T. Ishihara, T. Takada, Y. Shoji, Y. Uedono, N. Takeyama, T. Tanaka
- Chemistry, Medicine
- General pharmacology
- 1 July 1998
It is suggested that the synthesis of endogenous nitric oxide from L-arginine is accelerated by continuous ammonium acetate infusion when the urea cycle remains intact and has a substantial cytoprotective effect on the stomach, probably through maintaining the gastric mucosal microcirculation. Expand
Influence of aging on stress ulcer formation in rats.
- T. Ohno, H. Uramoto, Y. Masuda, H. Kubota, T. Ishihara
- Scandinavian journal of gastroenterology…
Results indicate that an insufficiency of gastric mucosal microvascular networks and the preserved gastric acid response in the vulnerable mucosa may be involved in the mechanisms underlying aggravation of stress ulcer formation in aged rats. Expand
Surface epithelial cell damage induced by restraint and water-immersion stress in rats effects of 16,16-dimethyl prostaglandin E2 on stress-induced gastric lesions.
Results indicated that stress induced damage to the gastric mucosa within 1 hr due to increased gastric contractions, and the surface epithelial cell damage developed into macroscopically visible lesions in the presence of acid, and that dmPGE2 protected thesurface epithelium against stress-induced damage probably by inhibiting gastriccontractions. Expand
Acute left ventricular failure and effects of angiotensin converting enzyme inhibitors in the anesthetized open chest dogs
Effects of Angiotensin Converting Enzyme Inhibitors on Acute Heart Failure Induced in the Anesthetized Dog with Microsphere Injection
A new model of ALVF was developed by embolization of the left coronary artery with 50 urn plastic microspheres followed by intravenous infusion of methoxamine to study the effects of angiotensin converting enzyme (ACE) inhibitors on myocardial energy metabolism together with their effects on hemodynamic parameters in acute left ventricular failure. Expand
An efficacy of ventricular extrastimulus testing during basic ventricular and atrial simultaneous pacing for analysis of V-A conduction in a case of uncommon atrio-ventricular nodal reentrant…
The history of AVNRT, a closed-loop system for smartphones, in action. Expand