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A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin.
TLDR
The data suggest that a short corticotropin test has a good prognostic value and could be helpful in identifying patients with septic shock at high risk for death.
Hydrocortisone plus Fludrocortisone for Adults with Septic Shock
TLDR
In this trial involving patients with septic shock, 90‐day all‐cause mortality was lower among those who received hydrocortisone plus fludrocort isone or with drotrecogin alfa (activated), the combination of the three drugs, or their respective placebos.
Septic shock
Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
TLDR
For all trials, regardless of duration of treatment and dose, use of corticosteroids did not significantly affect mortality, however, mortality at 28 days and hospital morality was reduced with long courses of low doses of cortiosteroids.
Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review.
TLDR
The benefits and risks of corticosteroid treatment in severe sepsis and septic shock and the influence of dose and duration are examined and analysis of this subgroup suggests a beneficial drug effect on short-term mortality.
Incidence and prognosis of sustained arrhythmias in critically ill patients.
TLDR
Sustained arrhythmias are observed in 12% of patients admitted to general ICUs, and after adjusting for prognosis factors and propensity scores, ventricular arrh rhythmias still increased mortality but supraventricular arrHythmias and conduction abnormalities did not.
Corticosteroids for treating sepsis.
TLDR
The quality of evidence for this outcome was downgraded from high to low for imprecision (upper limit of 95% CI = 1) and for inconsistency (significant heterogeneity across trial results).
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