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Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy.
Observations indicated that carvedilol has beneficial effects and protects cardiac adrenergic neurons in dilated cardiomyopathy in rats studied in a rat model of dilated heart failure after autoimmune myocarditis. Expand
Expression of inducible nitric oxide synthase in rat experimental autoimmune myocarditis with special reference to changes in cardiac hemodynamics.
An important role for NO is suggested in mediating pathophysiological changes in myocarditis of autoimmune origin and was localized to the infiltrating inflammatory cells found in the vicinity of necrotic myocytes by immunohistochemical analysis. Expand
Protection Against Autoimmune Myocarditis by Gene Transfer of Interleukin-10 by Electroporation
Findings showed that gene transfer into muscle by electroporation in vivo is an effective means of delivery of IL-10 for the treatment of autoimmune myocarditis. Expand
Strain‐ and age‐dependent loss of sarcoglycan complex in cardiomyopathic hamster hearts and its re‐expression by δ‐sarcoglycan gene transfer in vivo
Immunological analyses of heart before, but not after, the progression of cardiomyopathy revealed that the BIO 14.6 strain, a model of hypertrophic CM, heterogeneously preserved α and γ‐SG with loss of β‐ and δ‐SG, while the TO‐2 strain did not show either SG. Expand
Rp-8-Br-guanosine-3',5'-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta.
To ascertain whether the activation of cyclic GMP-dependent protein kinase is involved in the relaxant effects of nitroglycerin, the effects of Rp-8-Br-guanosine-3',5'-cyclic monophosphorothioateExpand
Translocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure: a scheme for the progression of cardiac dysfunction.
Using TO-2 hamsters with hereditary dilated cardiomyopathy, age-dependent cleavage and translocation of myocardial dystrophin from the sarcolemma to the myoplasm is shown, increased SL permeability in situ, and a close relationship between the loss of Dys and hemodynamic indices. Expand
Effects of l- and d‐Propranolol on the Ischemic Myocardial Metabolism of the Isolated Guinea Pig Heart, as Studied by 31P‐NMR
It is suggested that not only l-propranolol, but also d-pro Pranolol can produce beneficial effects on the ischemic derangements of myocardial energy metabolism. Expand
Effect of Hydrodynamics-Based Gene Delivery of Plasmid DNA Encoding Interleukin-1 Receptor Antagonist-Ig for Treatment of Rat Autoimmune Myocarditis: Possible Mechanism for Lymphocytes and Noncardiac
EAM was suppressed by hydrodynamics-based delivery of plasmid DNA encoding IL-1RA-Ig and the expression of immune-relevant genes within noncardiomyocytic cells cultured from EAM hearts or concanavalin A-stimulated lymphocytes derived from lymph nodes in EAM-affected rats. Expand
Effects of three different Ca(2+) pump ATPase inhibitors on evoked contractions in rabbit aorta and activities of Ca(2+) pump ATPases in porcine aorta.
The data suggest that CPA, TG and tBHQ can all act as selective SERCA inhibitors in both porcine and rabbit aortic smooth muscle, however, in contrast to CPA and TG, high concentrations of tB HQ can exhibit some nonspecific effects, which include inhibition of the plasma membrane Ca(2+)-ATPase and possibly K(+) channels regulated by cromakalim. Expand
Ethanol ingestion on allylamine-induced experimental subendocardial fibrosis.
The vasodilatory effect of ethanol may have prevented the development of microvascular spasm induced by allylamine, and the effects were significant in animals additionally treated with epinephrine. Expand