Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 225,168,511 papers from all fields of science
Search
Sign In
Create Free Account
sparfosic acid
Known as:
N-(phosphonoacetyl)-L-aspartic acid
, PALA
, n-phosphonacetyl-l-aspartic acid
Expand
A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
16 relations
Broader (5)
Antimetabolites, Antineoplastic
Antiviral Agents
Aspartic Acid
Enzyme Inhibitors
Expand
CAD Protein
N-Phosphonacetyl-L-aspartate
NCIt Antineoplastic Agent Terminology
RNA Synthesis Inhibition
Expand
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Interference of outer membrane protein PalA with protective immunity against Actinobacillus pleuropneumoniae infections in vaccinated pigs.
H. van den Bosch
,
J. Frey
Vaccine
2003
Corpus ID: 8777426
Highly Cited
1996
Highly Cited
1996
In vivo formation of allosteric aspartate transcarbamoylase containing circularly permuted catalytic polypeptide chains: Implications for protein folding and assembly
Pinghui Zhang
,
H. K. Schachman
Protein Science
1996
Corpus ID: 21640393
Because the N‐ and C‐terminal amino acids of the catalytic (c) polypeptide chains of Escherichia coli aspartate transcarbamoylase…
Expand
1995
1995
X-ray scattering titration of the quaternary structure transition of aspartate transcarbamylase with a bisubstrate analogue: influence of nucleotide effectors.
L. Fetler
,
P. Tauc
,
G. Hervé
,
M. F. Moody
,
P. Vachette
Journal of Molecular Biology
1995
Corpus ID: 11020585
The regulation of aspartate transcarbamylase (ATCase) involves various conformational changes, including a large quaternary…
Expand
1995
1995
p53-dependent growth arrest of REF52 cells containing newly amplified DNA.
Y. Ishizaka
,
M. V. Chernov
,
C. Burns
,
G. Stark
Proceedings of the National Academy of Sciences…
1995
Corpus ID: 40590412
The rat cell line REF52 is not permissive for gene amplification. Simian virus 40 tumor (T) antigen converts these cells to a…
Expand
Highly Cited
1989
Highly Cited
1989
Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells.
Edward Otto
,
Susan McCord
,
Thea D. TlstyQ
Journal of Biological Chemistry
1989
Corpus ID: 24192478
Highly Cited
1985
Highly Cited
1985
Quaternary structure changes in aspartate transcarbamylase studied by X-ray solution scattering. Signal transmission following effector binding.
G. Hervé
,
M. F. Moody
,
P. Tauc
,
P. Vachette
,
P. T. Jones
Journal of Molecular Biology
1985
Corpus ID: 36728387
1983
1983
Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate
Janine Zieg
,
Christine Clayton
,
F. Ardeshir
,
Elena Giulotto
,
E. A. Swyryd
,
G R Stark
Molecular and Cellular Biology
1983
Corpus ID: 2451821
Eleven independent lines of Syrian hamster cells were selected by using very low levels of N-(phosphonacetyl)-L-aspartate (PALA…
Expand
Highly Cited
1981
Highly Cited
1981
The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker
B. Vincent
,
S. Delbrück
,
W. Eckhart
,
J. Meinkoth
,
Louise Vitto
,
G. Wahl
Cell
1981
Corpus ID: 1767435
1979
1979
Mechanisms of sensitivity or resistance of murine tumors to N-(phosphonacetyl)-L-aspartate (PALA).
H. Jayaram
,
D. Cooney
,
D. Vistica
,
S. Kariya
,
R. Johnson
Cancer treatment reports
1979
Corpus ID: 21352544
Several biochemical parameters were examined relative to the sensitivity or resistance of representative rodent tumors to N…
Expand
1973
1973
Aspartate transcarbamylase from Escherichia coli. The use of pyridoxal 5'-phosphate as a probe in the active site.
P. Greenwell
,
S. Jewett
,
G. Stark
Journal of Biological Chemistry
1973
Corpus ID: 33974485
Abstract Spectrophotometric titration studies at pH 8.0 have revealed that pyridoxal 5'-phosphate binds as a Schiff base to the…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE