sparfosic acid

Known as: N-(phosphonoacetyl)-L-aspartic acid, PALA, n-phosphonacetyl-l-aspartic acid 
A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1973-2017
0102019732017

Papers overview

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Highly Cited
2007
Highly Cited
2007
PURPOSE There are no good genomic markers of survival in patients with advanced colorectal cancer. The CpG island methylator… (More)
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Highly Cited
2003
Highly Cited
2003
Modification-specific antibodies were used to characterize the phosphorylation and acetylation of human p53 in response to… (More)
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Highly Cited
1999
Highly Cited
1999
Overexpression of the MYC protooncogene has been implicated in the genesis of diverse human tumors. Tumorigenesis induced by MYC… (More)
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1998
1998
Normal mammalian cells arrest primarily in G1 in response to N-(phosphonacetyl)-L-aspartate (PALA), which starves them for… (More)
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1996
1996
Alterations in expression of or responsiveness to transforming growth factor beta (TGF-beta) are frequently found in human and… (More)
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Highly Cited
1994
Highly Cited
1994
The tumor suppressor protein p53 serves as a critical regulator of a G1 cell cycle checkpoint and of apoptosis following exposure… (More)
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Highly Cited
1992
Highly Cited
1992
Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor… (More)
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1983
1983
Two human brain tumors which were previously established in nude mice were used to determine antitumor efficacy of various… (More)
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1979
1979
Mutant Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a transition state analog inhibitor of aspartate… (More)
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1976
1976
Upon exposure to 0.1 mM N-phosphonacetyl-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase… (More)
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