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sparfosic acid

Known as: N-(phosphonoacetyl)-L-aspartic acid, PALA, n-phosphonacetyl-l-aspartic acid 
A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable… 
National Institutes of Health

Related topics

Related topics

16 relations

Broader (5)

Antimetabolites, AntineoplasticAntiviral AgentsAspartic AcidEnzyme Inhibitors
CAD ProteinN-Phosphonacetyl-L-aspartateNCIt Antineoplastic Agent TerminologyRNA Synthesis Inhibition

Papers overview

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1985
1985
N-(Phosphonoacetyl)amino phosphonates. Phosphonate analogues of N-(phosphonoacetyl)-L-aspartic acid (PALA).
Michaelis-Arbuzov reaction of N-(chloroacetyl)amino phosphonic acids or their esters, followed by acidolysis, gives moderate… 
1985
1985
Design and synthesis of new transition-state analogue inhibitors of aspartate transcarbamylase.
Six transition-state or bisubstrate analogue inhibitors (6-11) have been designed, synthesized, and tested against aspartate… 
1985
1985
Modulation of the activity of PALA by dipyridamole.
PALA is thought to inhibit an early step in de novo pyrimidine synthesis, causing depletion of intracellular pyrimidine… 
1984
1984
Phase II trial of PALA in lymphoma: an Eastern Cooperative Oncology Group study.
A phase II trial of PALA in malignant lymphoma was carried out by the Eastern Cooperative Oncology Group. The occurrence of… 
1984
1984
Role of Endocytosis and Lysosomal pH in Uptake of N-(Phosphonacetyl)-l-aspartate and Its Inhibition of Pyrimidine Synthesis
The mechanism of uptake and retention of N -(phosphonacetyl)-l-aspartate (PALA) was examined. Uptake of [3H]PALA by Ehrlich… 
1981
1981
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.
Variants of the Lewis lung carcinoma were selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of… 
1980
1980
Phase II evaluation of N-(phosphonacetyl)-L-aspartic acid (PALA) in patients with non-small cell carcinoma of the lung.
1980
1980
Phase I trial of PALA.
PALA was given iv on a weekly schedule to 32 patients with advanced malignant tumors. A course of treatment consisted of three… 
1977
1977
Selective inhibition of pyrimidine biosynthesis and effect on proliferative growth of colonic cancer cells.
A highly selective inhibition of de novo pyrimidine synthesis in the intact cell has been demonstrated by the action of N… 
1973
1973
Aspartate transcarbamylase from Escherichia coli. The use of pyridoxal 5'-phosphate as a probe in the active site.
Abstract Spectrophotometric titration studies at pH 8.0 have revealed that pyridoxal 5'-phosphate binds as a Schiff base to the… 
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