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sparfosic acid

Known as: N-(phosphonoacetyl)-L-aspartic acid, PALA, n-phosphonacetyl-l-aspartic acid 
A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable… Expand
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
The importance of normal distribution is undeniable since it is an underlying assumption of many statistical procedures such as t… Expand
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Highly Cited
2010
Highly Cited
2010
Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: There are no good genomic markers of survival in patients with advanced colorectal cancer. The CpG island methylator… Expand
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Highly Cited
2004
Highly Cited
2004
SummaryIn the fungus Aspergillus nidulans the levels of a number of enzymes whose location is at least in part extracellular (e.g… Expand
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Highly Cited
2003
Highly Cited
2003
Modification-specific antibodies were used to characterize the phosphorylation and acetylation of human p53 in response to… Expand
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Highly Cited
2003
Highly Cited
2003
SUMMARY Pathogenic fungi have successfully attacked a wide range of hosts, which has forced them into ambient-adaptation. pH is… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT The zinc finger transcription factor PacC undergoes two-step proteolytic activation in response to alkaline ambient pH… Expand
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Highly Cited
1999
Highly Cited
1999
Overexpression of the MYC protooncogene has been implicated in the genesis of diverse human tumors. Tumorigenesis induced by MYC… Expand
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Highly Cited
1998
Highly Cited
1998
Normal mammalian cells arrest primarily in G1 in response to N-(phosphonacetyl)-L-aspartate (PALA), which starves them for… Expand
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Highly Cited
1983
Highly Cited
1983
Two human brain tumors which were previously established in nude mice were used to determine antitumor efficacy of various… Expand
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