Skip to search formSkip to main contentSkip to account menu

sparfosic acid

Known as: N-(phosphonoacetyl)-L-aspartic acid, PALA, n-phosphonacetyl-l-aspartic acid 
A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable… 
National Institutes of Health

Related topics

Related topics

16 relations

Broader (5)

Antimetabolites, AntineoplasticAntiviral AgentsAspartic AcidEnzyme Inhibitors
CAD ProteinN-Phosphonacetyl-L-aspartateNCIt Antineoplastic Agent TerminologyRNA Synthesis Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Interference of outer membrane protein PalA with protective immunity against Actinobacillus pleuropneumoniae infections in vaccinated pigs.
Highly Cited
1996
Highly Cited
1996
In vivo formation of allosteric aspartate transcarbamoylase containing circularly permuted catalytic polypeptide chains: Implications for protein folding and assembly
Because the N‐ and C‐terminal amino acids of the catalytic (c) polypeptide chains of Escherichia coli aspartate transcarbamoylase… 
1995
1995
X-ray scattering titration of the quaternary structure transition of aspartate transcarbamylase with a bisubstrate analogue: influence of nucleotide effectors.
The regulation of aspartate transcarbamylase (ATCase) involves various conformational changes, including a large quaternary… 
1995
1995
p53-dependent growth arrest of REF52 cells containing newly amplified DNA.
The rat cell line REF52 is not permissive for gene amplification. Simian virus 40 tumor (T) antigen converts these cells to a… 
Highly Cited
1989
Highly Cited
1989
Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells.
Highly Cited
1985
Highly Cited
1985
Quaternary structure changes in aspartate transcarbamylase studied by X-ray solution scattering. Signal transmission following effector binding.
1983
1983
Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate
Eleven independent lines of Syrian hamster cells were selected by using very low levels of N-(phosphonacetyl)-L-aspartate (PALA… 
Highly Cited
1981
Highly Cited
1981
The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker
1979
1979
Mechanisms of sensitivity or resistance of murine tumors to N-(phosphonacetyl)-L-aspartate (PALA).
Several biochemical parameters were examined relative to the sensitivity or resistance of representative rodent tumors to N… 
1973
1973
Aspartate transcarbamylase from Escherichia coli. The use of pyridoxal 5'-phosphate as a probe in the active site.
Abstract Spectrophotometric titration studies at pH 8.0 have revealed that pyridoxal 5'-phosphate binds as a Schiff base to the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)