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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with evaluating data suggestingExpand
Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells
The H2B-GFP system allows the high-resolution imaging of chromosomes, including DMs, without compromising nuclear and chromosomal structures and has revealed the distinctive clustering behavior of DMs in mitotic cells which contributes to their asymmetric distribution to daughter cells. Expand
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
This Review of in vitro studies, human tumour data and recent mouse models shows that p53 post-translational modifications have modulatory roles, and MDM2 andMDM4 have more profound roles for regulating p53. Expand
MDM2, MDMX and p53 in oncogenesis and cancer therapy
This Review highlights the progress made and pitfalls encountered as the field continues to search for MDM-targeted antitumour agents. Expand
A leucine‐rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking
A model in which regulated p53 tetramerization occludes its NES is proposed, thereby ensuring nuclear retention of the DNA‐binding form and suggesting that attenuation of p53 function involves the conversion of tetramers into monomers or dimers, in which the NES is exposed to the proteins which mediate their export to the cytoplasm. Expand
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability.
It is proposed that oncogene activation can induce DNA damage and override damage controls, thereby accelerating tumor progression via genetic instability. Expand
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.
Ten percent dextran sulfate accelerates the rate of hybridization of randomly cleaved double-stranded DNA probes to immobilized nucleic acids by as much as 100-fold, without increasing the background significantly. Expand
Hybridization of nucleic acids immobilized on solid supports.
Linking the p53 tumor suppressor pathway to somatic cell reprogramming
It is shown that reprogramming factors can activate the p53 (also known as Trp53 in mice, TP53 in humans) pathway and silencing of p53 significantly increased the reprograming efficiency of human somatic cells. Expand
The p53 orchestra: Mdm2 and Mdmx set the tone.
Roles for Mdm2 and Mdmx in additional cancer-related networks are considered, including Notch signaling and the epithelial-to-mesenchymal transition. Expand