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Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells.

TLDR
Findings show that p210 bcr-abl transduces proliferative signals, in part, through downstream activation of p21 RAS, which is linked to pathways that regulate c-jun and c-fos expression.
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Mechanisms of sensitivity or resistance of murine tumors to N-(phosphonacetyl)-L-aspartate (PALA).

TLDR
Several biochemical parameters examined relative to the sensitivity or resistance of representative rodent tumors to N-(phosphonacetyl)-L-aspartate (PALA) found to have no association with sensitivity to PALA in vivo.
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Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.

TLDR
Variants of the Lewis lung carcinoma selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of tumor-bearing mice with repetitive subcurative doses of PALA may serve to competitively displace PALA from ATCase, diminish enzyme inhibition, and allow pyrimidine biosynthesis to proceed despite therapy.
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Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.

TLDR
The inhibitory effects of ethanol on H(2)O(2)-induced AMPK phosphorylation were attenuated by the presence of the PP2A inhibitor, okadaic acid, orPP2A siRNA, and the inhibition of PKC-zeta and LKB1 phosphorylated and the activation of PP2 A.
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NMNAT expression and its relation to NAD metabolism.

TLDR
Steps involved in NAD synthesis are being utilized as targets for chemoprevention, radiosensitization and therapy of wide range of diseases, such as cancer, multiple sclerosis, neurodegeneration and Huntington's disease.
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Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.

TLDR
The activation of phospholipase D by sphingosine was not abolished by treatment of BPAEC with either cholera or pertussis toxin, indicating noninvolvement of toxin-sensitive G-proteins.
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Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.

TLDR
It is suggested that homocysteine is the key modulator of translational upregulation of FRs and establishes the linkage between perturbed folate metabolism and coordinated upregulationof FRs.
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Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193).

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Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.

TLDR
Tiazofurin was better tolerated in most patients than other antileukemic treatment modalities and provided a rational,Biochemically targeted, and biochemically monitored chemotherapy which should be of interest in the treatment of leukemias and as a paradigm in enzyme pattern-targeted chemotherapy.
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Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis.

TLDR
Inosine 5 -monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme for the synthesis of GTP and dGTP that plays an important role in the expression of cellular genes, such as p53, c-myc and Ki-ras.
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