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- Publications
- Influence
Role of p21 RAS in p210 bcr-abl transformation of murine myeloid cells.
- R. A. Mandanas, D. Leibowitz, +5 authors H. S. Boswell
- Biology, Medicine
- Blood
- 15 September 1993
The p21 RAS product has been implicated as part of the downstream signaling of certain nonreceptor tyrosine kinase oncogenes and several growth factor receptor-ligand interactions. We have reported… Expand
NMNAT expression and its relation to NAD metabolism.
- H. Jayaram, P. Kusumanchi, J. Yalowitz
- Biology, Medicine
- Current medicinal chemistry
- 1 May 2011
Nicotinamide mononucleotide adenylyltransferease (NMNAT), a rate-limiting enzyme present in all organisms, reversibly catalyzes the important step in the biosynthesis of NAD from ATP and NMN. NAD and… Expand
Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.
- A. Antony, Ying-Sheng Tang, +6 authors S. Stabler
- Biology, Medicine
- The Journal of clinical investigation
- 15 January 2004
Cellular acquisition of folate is mediated by folate receptors (FRs) in many malignant and normal human cells. Although FRs are upregulated in folate deficiency and downregulated following folate… Expand
Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.
- S. Liangpunsakul, Sung-Eun Wou, Y. Zeng, R. Ross, H. Jayaram, D. Crabb
- Chemistry, Medicine
- American journal of physiology. Gastrointestinal…
- 1 December 2008
AMP-activated protein kinase (AMPK) responds to oxidative stress. Previous work has shown that ethanol treatment of cultured hepatoma cells and of mice inhibited the activity of AMPK and reduced the… Expand
Initial studies on the mechanism of action of a new oncolytic thiazole nucleoside, 2-beta-D-ribofuranosylthiazole-4-carboxamide (NSC 286193).
- H. Jayaram, R. Dion, +4 authors D. Cooney
- Biology, Medicine
- Biochemical pharmacology
- 15 July 1982
Studies on the mechanism of action of a new oncolytic nucleoside, 2-β-d-ribofuranosylthiazole-4-carboxamide, have been undertaken using P388 murine leukemia cells growing in culture. The title… Expand
Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity.
- G. Tricot, H. Jayaram, +6 authors R. Hoffman
- Medicine
- Cancer research
- 1 July 1989
Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193), a selective inhibitor of the activity of IMP dehydrogenase (EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis,… Expand
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.
- T. Kensler, G. Mutter, +8 authors D. Cooney
- Biology, Medicine
- Cancer research
- 1 March 1981
Variants of the Lewis lung carcinoma were selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of tumor-bearing mice with repetitive subcurative doses of PALA. The… Expand
Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.
- V. Natarajan, H. Jayaram, W. M. Scribner, J. Garcia
- Chemistry, Medicine
- American journal of respiratory cell and…
- 1 August 1994
We have investigated the activation of phospholipase D (PLD) by sphingosine and its derivatives in bovine pulmonary artery endothelial cells (BPAEC) prelabeled with [32P]orthophosphate or [32P]lyso… Expand
Isolation and Characterization of a Folate Receptor mRNA-binding trans-Factor from Human Placenta
- X. Xiao, Y. Tang, +4 authors A. Antony
- Biology, Medicine
- The Journal of Biological Chemistry
- 2 November 2001
The interaction of an 18-basecis-element in the 5′-untranslated region of human folate receptor (FR)-α mRNA with a cytosolic trans-factor protein is critical for the translation of FR (Sun, X.-L.,… Expand
Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.
- B. Ardalan, D. Cooney, +4 authors P. Schein
- Biology, Medicine
- Cancer research
- 1 May 1980
The biochemical basis for the resistance of murine leukemia P388 to 5-fluorouracil (FUra) was systematically investigated by examining the transport and metabolism of FUra, or its anabolites, as well… Expand