• Publications
  • Influence
Intraneuronal Abeta42 accumulation in human brain.
Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated beta-amyloid (Abeta)Expand
  • 406
  • 29
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the protein, leading to the production of a fragment referred to as N1.Expand
  • 296
  • 19
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
Amyloid beta-peptide (Abeta), which plays a central role in Alzheimer's disease, is generated by presenilin-dependent gamma-secretase cleavage of beta-amyloid precursor protein (betaAPP). We reportExpand
  • 306
  • 7
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.
Amyloid beta-peptide (Abeta), which plays a central role in Alzheimer's disease, is generated by presenilin-dependent gamma-secretase cleavage of beta-amyloid precursor protein (betaAPP). We reportExpand
  • 158
  • 6
Étude du benthos d'eau douce dans le haut estuaire du Saint-Laurent (Québec)
Nous avons etudie le benthos recolte dans 37 stations du Saint-Laurent qui sont echelonnees sur une distance de 230 km, entre le lac Saint-Pierre et l'ile aux Oies. L'examen de la repartition desExpand
  • 18
  • 6
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid β-amyloid (Aβ) peptides, and autosomal dominant forms of AD appear to cause diseaseExpand
  • 392
  • 5
  • PDF
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid beta-amyloid (Abeta) peptides, and autosomal dominant forms of AD appear to causeExpand
  • 172
  • 5
Assessing Species Distribution Using Google Street View: A Pilot Study with the Pine Processionary Moth
TLDR
A survey to explore to which extent large-scale databases such as Google maps and Google street view could be used to derive valid occurrence data. Expand
  • 42
  • 4
  • PDF
Fecundity and larval development of Monochamus galloprovincialis (Coleoptera Cerambycidae) in experimental breeding
Abstract•The study aimed at clarifying basic life traits (fecundity, mortality and development) of Monochamus galloprovincialis, the vector of Bursaphelenchus xylophilus, the causative agent of theExpand
  • 27
  • 4
  • PDF
Presenilin-Dependent γ-Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease
Presenilins (PSs) are part of the γ-secretase complex that produces the amyloid β-peptide (Aβ) from its precursor [β-amyloid precursor protein (βAPP)]. Mutations in PS that cause familial Alzheimer'sExpand
  • 117
  • 3