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saruplase

Known as: prourokinase (enzyme-activating), recombinant unglycosylated single-chain urokinase-type plasminogen activator, pro-urokinase 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

A-74187

Broader (3)

Fibrinolytic AgentsRecombinant ProteinsUrokinase

Papers overview

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2002
2002
Glycosylation affects the rate of traffic of the Shaker potassium channel through the secretory pathway.
We have examined the effect of glycosylation on the traffic of the voltage-gated Shaker potassium channel through the secretory… 
2002
2002
High-level production of prourokinase-annexin V chimeras in the methylotrophic yeast Pichia pastoris.
Review
2001
Review
2001
Thrombolysis in Pulmonary Embolism: A Debatable Indication
Summary Successfully utilized contemporary pulmonary embolism thrombolysis reverses right heart failure rapidly and safely. This… 
1998
1998
Rapid Haemodynamic Improvement Following Saruplase in Recent Massive Pulmonary Embolism
Summary In a single centre pilot study, saruplase (20 mg bolus plus 60 mg infusion over 1 h) was administered to twenty patients… 
1997
1997
Effect of Changes in Liver Blood Flow on the Pharmacokinetics of Saruplase in Patients with Acute Myocardial Infarction
Summary Background: The recombinant unglycosylated single chain urokinase-type plasminogen activator saruplase is cleared for a… 
1993
1993
Pharmacokinetics of Saruplase, a Recombinant Unglycosylated Human Single-Chain Urokinase-Type Plasminogen Activator and Its Effects on Fibrinolytic and Haemostatic Parameters in Healthy Male Subjects
Summary Pharmacokinetics of two doses of the recombinant single-chain urokinase-type plasminogen activator (r-scu-PA) saruplase… 
1991
1991
Enhancement of the thrombolytic efficacy of prourokinase by lys-plasminogen in a dog model of arterial thrombosis.
1990
1990
Continuous production of prourokinase in feed harvest and perfusion cultures
The production of prourokinase (PUK) by a human kidney tumor cell line is studied in long term cultures. Cells are grown on… 
1990
1990
Interactions of saruplase with acetylsalicylic acid, heparin, glyceryl trinitrate, tranexamic acid and aprotinin in a rabbit pulmonary thrombosis model.
In anesthetized rabbits with pulmonary embolized thrombi the interactions of saruplase (recombinant unglycosylated single-chain… 
1990
1990
Comparison of intravenous bolus injection or continuous infusion of recombinant single chain urokinase-type plasminogen activator (saruplase) for thrombolysis. A canine model of combined coronary…
The thrombolytic efficacy of recombinant unglycosylated full length single chain urokinase-type plasminogen activator (rscu-PA… 
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