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Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.
- C. Hertweck, A. Luzhetskyy, Yuri Rebets, A. Bechthold
- Chemistry, Medicine
- Natural product reports
- 31 January 2007
This review covers advances in understanding of the biosynthesis of polyketides produced by type II PKS systems at the genetic, biochemical and structural levels.
Genes and enzymes involved in deoxysugar biosynthesis in bacteria.
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis.
- M. Berner, Daniel Krug, C. Bihlmaier, A. Vente, R. Mueller, A. Bechthold
- Biology, Medicine
- Journal of bacteriology
- 1 April 2006
The saccharomicins A and B, produced by the actinomycete Saccharothrix espanaensis, are oligosaccharide antibiotics. They consist of 17 monosaccharide units and the unique aglycon… Expand
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.
- L. Westrich, S. Domann, B. Faust, D. Bedford, D. Hopwood, A. Bechthold
- Biology, Medicine
- FEMS microbiology letters
From a cosmid library of Streptomyces cyanogenus S136, DNA fragments encompassing approximately 35 kb of the presumed landomycin biosynthetic gene cluster were identified and sequenced, revealing 32… Expand
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host.
BACKGROUND The granaticins are members of the benzoisochromanequinone class of aromatic polyketides, the best known member of which is actinorhodin made by Streptomyces coelicolor A3(2). Genetic… Expand
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose
Avilamycin is an orthosomycin antibiotic that has shown considerable potential for clinical use, although it is presently used as a growth promoter in animal feed. Avilamycin inhibits bacterial… Expand
Marker removal from actinomycetes genome using Flp recombinase.
We report here a system for the functional expression of the Flp recombinase in several actinomycetes: Streptomyces coelicolor, S. lividans, and Saccharotrix espanaensis. We have constructed a… Expand
StreptomeDB 2.0—an extended resource of natural products produced by streptomycetes
- Dennis Klementz, Kersten Döring, +8 authors S. Günther
- Medicine, Computer Science
- Nucleic Acids Res.
- 28 November 2015
Over the last decades, the genus Streptomyces has stirred huge interest in the scientific community as a source of bioactive compounds. The majority of all known antibiotics is isolated from these… Expand
Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase for shikonin biosynthesis in Lithospermum erythrorhizon cell suspension cultures
Abstract. The carbon skeleton of the naphthoquinone pigment shikonin, which is produced in Lithospermum erythrorhizon Sieb. et Zucc. cell-suspension cultures, is partly derived from the isoprenoid… Expand
The future of natural products as a source of new antibiotics.
- A. Luzhetskyy, S. Pelzer, A. Bechthold
- Business, Medicine
- Current opinion in investigational drugs
- 1 August 2007
One reason for the current crisis in antibiotic development is the low return on investment, which is intrinsic to anti-infective drug development. Despite this, smaller pharmaceutical companies are… Expand