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A perivascular origin for mesenchymal stem cells in multiple human organs.
Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells. Expand
An overview of tissue and whole organ decellularization processes.
Tissue decellularization with preservation of ECM integrity and bioactivity can be optimized by making educated decisions regarding the agents and techniques utilized during processing. Expand
Decellularization of tissues and organs.
The most commonly used decellularization methods are described, and consideration give to the effects of these methods upon the biologic scaffold material. Expand
Extracellular matrix as a biological scaffold material: Structure and function.
An overview of the composition and structure of selected ECM scaffolding materials, the effects of manufacturing methods upon the structural properties and resulting mechanical behavior of the scaffold materials, and the in vivo degradation and remodeling of ECm scaffolds with an emphasis on tissue function is provided. Expand
Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds.
The fundamental concepts of whole-organ engineering, including characterization of the extracellular matrix as a scaffold, methods for decellularization of vascular organs, potential cells to reseed such a scaffolds, techniques for the recellularization process and important aspects regarding bioreactor design to support this approach are described. Expand
Macrophage phenotype as a determinant of biologic scaffold remodeling.
A rat model was used to determine the macrophage phenotype at the site of implantation of two biologic scaffolds that differed mainly according to their method of processing: the Restore device (SIS) and the CuffPatch device (carbodiimide crosslinked form of porcine-derived SIS). Expand
The extracellular matrix as a biologic scaffold material.
  • S. Badylak
  • Materials Science, Medicine
  • Biomaterials
  • 1 September 2007
The factors that appear important for the constructive remodeling of ECM biologic scaffolds are its ability to be rapidly and completely degraded with the generation of downstream bioactive molecules and the ability to engineer its mechanical properties at the time of implantation through an understanding of its collagen fiber microstructure. Expand
Quantification of DNA in biologic scaffold materials.
The majority of DNA is removed from ECM devices but that small amounts remained in most tested materials, showing the efficacy of decellularization procedures. Expand
Differential expression of muscle regulatory factor genes in normal and denervated adult rat hindlimb muscles
Examination of the expression patterns of four basic/helix‐loop‐helix muscle regulatory factors (MRFs) in normal adult rat muscles suggest that myogenin, as well as the other three MRFs, may be involved in both the initial establishment aswell as maintenance of fiber‐type diversity in the developing organism. Expand
The extracellular matrix as a scaffold for tissue reconstruction.
  • S. Badylak
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 1 October 2002
Xenogeneic and allogeneic ECM has been used as a bioscaffold for the reconstruction of many different tissue types in both pre-clinical and human clinical studies. Expand