Skip to search formSkip to main contentSkip to account menu

sagopilone

Known as: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-10-(prop-2-enyl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione 
A fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

BenzothiazolesEpothilones
Microtubule ProcessNegative Regulation of Microtubule Depolymerization

Narrower (4)

ZK-219477ZK-EPOZK-Epothiloneepothilone ZK-219477

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Biocatalysis at Work: Applications in the Development of Sagopilone
For the antitumour agent sagopilone, an epothilone analogue, a large‐scale synthesis was developed to synthesise the active… 
Review
2012
Review
2012
Novel drugs targeting microtubules: the role of epothilones.
Among the drugs targeting microtubule functions by interfering with tubulin subunits, epothilones represent a class of anticancer… 
2010
2010
Comparative Profiling of the Novel Epothilone, Sagopilone, in Xenografts Derived from Primary Non–Small Cell Lung Cancer
Purpose: Characterization of new anticancer drugs in a few xenograft models derived from established human cancer cell lines… 
2010
2010
Improving the ex vivo stability of drug ester compounds in rat and dog serum: inhibition of the specific esterases and implications on their identity.
Review
2009
Review
2009
Sagopilone, a microtubule stabilizer for the potential treatment of cancer.
Sagopilone (ZK-EPO), under development by Bayer Schering Pharma AG, is a novel, fully synthetic epothilone B analog that is… 
2009
2009
Phase II trial of sagopilone (ZK-EPO), a novel synthetic epothilone, with significant activity in metastatic melanoma.
9031 Background: Sagopilone (ZK-Epothilone) is a novel, fully synthetic epothilone with promising preclinical activity in several… 
Review
2008
Review
2008
Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate
Background: Tubulin is among the most established and clinically validated targets in oncology. The taxanes, paclitaxel and… 
2008
2008
Phase II study of sagopilone (ZK-EPO) plus prednisone as first-line chemotherapy in patients with metastatic androgen-independent prostate cancer (AIPC)
5141 Background: The microtubule stabilizer docetaxel, in combination with prednisone, prolongs life in patients with metastatic… 
2008
2008
A phase II study evaluating systemic sagopilone (ZK-EPO) treatment in patients with recurrent malignant gliomas
2083 Background: Sagopilone (ZK-EPO) is a fully synthetic epothilone that exhibits activity in MDR tumors, and has demonstrated… 
Review
2008
Review
2008
Ixabepilone in Metastatic Breast Cancer: Complement or Alternative to Taxanes?
Targeting the microtubule is a successful strategy in the treatment of solid tumors. There is an ongoing effort to develop newer… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)