• Publications
  • Influence
Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1 (NAT1).
TLDR
Functional consequences of NAT1 mutations were tested in a large population and there was no functional difference between NAT1 alleles *4 and *10, and alleles NAT1*11 and *14 appeared to be low activity alleles, and allele NAT1-15 had no activity. Expand
Concordance between enzyme activity and genotype of glutathione S-transferase theta (GSTT1).
TLDR
The results confirm the ethnic differences in the prevalence of the homozygous deleted genotype which were previously observed and seem to exist even between closely related ethnic groups such as German and Swedish populations. Expand
Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study.
TLDR
PNSC was significantly more effective in increasing skin hydration and elasticity than PN and NNSC indicating that phytosphingosine inducing the positive charge, SC lipids and ceramide 3B are crucial for the enhanced effect on skin hydrations and viscoelasticity. Expand
Stable cationic microparticles for enhanced model antigen delivery to dendritic cells.
TLDR
PLGA microparticles are suitable vehicles for protein delivery to DC, which might be used for DC-based cell therapies and also showed an enhanced model protein delivery into phagocytic cells. Expand
Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides.
TLDR
It was shown that PS was responsible for the positive charge and thus supported the high physical stability of PPNSC, and this optimised emulsion was selected for further skin absorption evaluation. Expand
Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells.
TLDR
Antioxidative treatment inhibited apoptosis and shedding of microparticles, thereby reducing thrombogenicity and may help to prevent late thromBosis after antiproliferative treatment when used in combination with anticoagulants. Expand
Tetracycline-HCl-loaded poly(DL-lactide-co-glycolide) microspheres prepared by a spray drying technique: influence of gamma-irradiation on radical formation and polymer degradation.
TLDR
It can be concluded that EPR spectroscopy in combination with GPC, DSC, and HPLC allows a detailed characterization of the impact of gamma-sterilization on biodegradable parenteral drug delivery systems. Expand
Poly(I:C) coated PLGA microparticles induce dendritic cell maturation.
TLDR
The concept of surface coating of biodegradable microparticles with selected TLR ligands might successfully be used in DC-based cell therapies for cancer or in vaccination trials to induce DC maturation and specifically amplify the immunological response to encapsulated antigens. Expand
Microenvironmental pH and microviscosity inside pH-controlled matrix tablets: an EPR imaging study.
TLDR
EPRI, a novel approach for monitoring pH(M) and tau(R) non-invasively and spatially resolved, was used successfully for the optimization of an pH-controlled formulation of HPMC matrix tablets. Expand
Penetration and release studies of positively and negatively charged nanoemulsions--is there a benefit of the positive charge?
TLDR
The results of the investigated positively charged nanoemulsion containing prednicarbate show that its topical use could be advantageous for the therapy of atopic dermatitis, especially regarding phytosphingosine, which was responsible for the positive charge. Expand
...
1
2
3
4
5
...