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MiR-200c and HuR in ovarian cancer
BackgroundMicroRNAs in solid malignancies can behave as predictors of either good or poor outcome. This is the case with members of the miR-200 family, which are the primary regulators of theExpand
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Molecular mechanisms of patupilone resistance.
Patupilone is an epothilone in advanced clinical development that has shown promising efficacy in heavily pretreated patients. This study aimed at characterizing the mechanisms of patupilone activityExpand
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Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness.
UNLABELLED SOX9 [(sex determining region Y)-box9] gene has been implicated in the development and progression of different neoplasms. This study investigated the role of Sox9 in the expression ofExpand
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Class III β-tubulin and the cytoskeletal gateway for drug resistance in ovarian cancer.
The Class III β-tubulin isotype (βIII-tubulin) is a predictive biomarker in ovarian cancer and other solid tumor malignancies. We discovered that βIII-tubulin function is linked to two GTPases:Expand
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Class III β-tubulin in normal and cancer tissues.
Microtubules are polymeric structures composed of tubulin subunits. Each subunit consists of a heterodimer of α- and β-tubulin. At least seven β-tubulin isotypes, or classes, have been identified inExpand
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HGF/c-Met axis drives cancer aggressiveness in the neo-adjuvant setting of ovarian cancer
// Marisa Mariani 1,2 , Mark McHugh 1 , Marco Petrillo 2 , Steven Sieber 1 , Shiquan He 1 , Mirko Andreoli 1,2 , Zheyang Wu 3 , Paul Fiedler 1 , Giovanni Scambia 2,4 , Shohreh Shahabi 1,* andExpand
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Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.
New arylthioindoles (ATIs) were obtained by replacing the 2-alkoxycarbonyl group with a bioisosteric 5-membered heterocycle nucleus. The new ATIs 5, 8, and 10 inhibited tubulin polymerization,Expand
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βIII-Tubulin: biomarker of taxane resistance or drug target?
Introduction: βIII-Tubulin (TUBB3) is predominantly expressed in neurons of the central and peripheral nervous systems, while in normal non-neoplastic tissues it is barely detectable. By contrast,Expand
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Somatic mutations and cell identity linked by Genotyping of Transcriptomes
Defining the transcriptomic identity of malignant cells is challenging in the absence of surface markers that distinguish cancer clones from one another, or from admixed non-neoplastic cells. ToExpand
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Identification of the First Inhibitor of the GBP1:PIM1 Interaction. Implications for the Development of a New Class of Anticancer Agents against Paclitaxel Resistant Cancer Cells
Class III β-tubulin plays a prominent role in the development of drug resistance to paclitaxel by allowing the incorporation of the GBP1 GTPase into microtubules. Once in the cytoskeleton, GBP1 bindsExpand
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