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Drug resistance and the solid tumor microenvironment.
Resistance of human tumors to anticancer drugs is most often ascribed to gene mutations, gene amplification, or epigenetic changes that influence the uptake, metabolism, or export of drugs fromExpand
Role of macrophage targeting in the antitumor activity of trabectedin.
There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic agent, induces rapid apoptosis exclusivelyExpand
Nucleoside analogues and nucleobases in cancer treatment.
Cytotoxic nucleoside analogues and nucleobases were among the first chemotherapeutic agents to be introduced for the medical treatment of cancer. This family of compounds has grown to include aExpand
A Review of Trabectedin (ET-743): A Unique Mechanism of Action
Trabectedin (ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata, with a chemical structure characterized by three fused tetrahydroisoquinoline rings. Two ofExpand
In vivo mechanisms of resistance to cytarabine in acute myeloid leukaemia
Summary.  Factors that reduce the intracellular concentration of triphosphorylated cytarabine (ara‐CTP), the active form of cytarabine (ara‐C), may induce chemoresistance in acute myeloid leukaemiaExpand
Trabectedin, a drug acting on both cancer cells and the tumour microenvironment
Trabectedin is the first marine-derived anti-neoplastic drug approved for the treatment of advanced soft tissue sarcoma and, in combination with pegylated liposomal doxorubicin, for the treatment ofExpand
Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations.
Resistance to fludarabine is observed in the clinic, and molecular predictive assays for benefit from chemotherapy are required. Our objective was to determine if expression of nucleoside transportExpand
Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics
In the present study, we compared the dynamics and composition of microtubules in cell lines derived from the human breast adenocarcinoma MCF-7 containing either the wild-type p53 (wt-p53; MN1) or aExpand
PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti‐tumour activity
BACKGROUND AND PURPOSE PM01183 is a new synthetic tetrahydroisoquinoline alkaloid that is currently in phase I clinical development for the treatment of solid tumours. In this study we haveExpand
Potential mechanisms of resistance to cytarabine in AML patients.
To determine whether the human equilibrative nucleoside transporter 1 (hENT1), deoxycytidine kinase (dCK), cytoplasmic 5'-nucleotidase (5NT), cytidine deaminase (CDD), topoisomerase I (TOPO I) andExpand