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epothilone ZK-219477

Known as: Epothilone ZK219477 
A novel synthetic epothilone with potential antineoplastic activity. Epothilone ZK-219477 binds to microtubules, predominantly in tumor cells… 
National Institutes of Health

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ZK-Epothilonesagopilone

Papers overview

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Review
2009
Review
2009
Activity of ixabepilone in oestrogen receptor-negative and oestrogen receptor-progesterone receptor-human epidermal growth factor receptor 2-negative metastatic breast cancer.
2006
2006
First-in-human phase I trial of a novel epothilone, KOS-1584.
2003 Background: KOS-1584 (9,10-didehydroepothilone D) was discovered as part of a screening program to develop a new generation… 
2005
2005
A phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors
2051 Background: Epothilones are a new class of cytotoxic agents that induce tubulin polymerization. ZK-EPO, the only fully… 
2005
2005
The epothilone dilemma.
Because of their potent antitumor activity, drugs targeting microtubules are among the most commonly prescribed anticancer agents… 
Highly Cited
2003
Highly Cited
2003
Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.
Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS… 
2003
2003
Potential radiation-sensitizing effect of semisynthetic epothilone B in human lung cancer cells.
2000
2000
Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.
The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of… 
Highly Cited
1999
Highly Cited
1999
Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.
1999
1999
Sets of aldolase antibodies with antipodal reactivities. Formal synthesis of epothilone E by large-scale antibody-catalyzed resolution of thiazole aldol.
[formula: see text] Three monoclonal aldolase antibodies, generated against a beta-diketone hapten by reactive immunization… 
1997
1997
Epothilone A induces apoptosis in neuroblastoma cells with multiple mechanisms of drug resistance.
Epothilone A, a novel macrolide antibiotic, is produced by the myxobacterium Sorangium cellulosum. Similarly to paclitaxel (Taxol… 
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