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epothilone ZK-219477

Known as: Epothilone ZK219477 
A novel synthetic epothilone with potential antineoplastic activity. Epothilone ZK-219477 binds to microtubules, predominantly in tumor cells… 
National Institutes of Health

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ZK-Epothilonesagopilone

Papers overview

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Review
2009
Review
2009
Activity of ixabepilone in oestrogen receptor-negative and oestrogen receptor-progesterone receptor-human epidermal growth factor receptor 2-negative metastatic breast cancer.
2007
2007
Phase II trial of the novel epothilone ZK-EPO in patients with platinum resistant ovarian cancer
5527 Background: The rationally designed, fully synthetic epothilone ZK-EPO has demonstrated significant activity against ovarian… 
2006
2006
A phase I trial of weekly combination KOS-862 (Epothilone D) and trastuzumab in HER-2 overexpressing malignancies.
2028 Background: KOS-862 (Epothilone D) (K) has shown single agent activity against metastatic breast cancer (MBC) and NSCLC… 
2005
2005
A phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors
2051 Background: Epothilones are a new class of cytotoxic agents that induce tubulin polymerization. ZK-EPO, the only fully… 
2005
2005
The epothilone dilemma.
Because of their potent antitumor activity, drugs targeting microtubules are among the most commonly prescribed anticancer agents… 
Review
2004
Review
2004
Epothilone D (Kosan/Roche).
Kosan and Roche are developing the microtubule inhibitor epothilone D (KOS-862 and NSC-703147), an analog of epothilone B for the… 
2003
2003
Potential radiation-sensitizing effect of semisynthetic epothilone B in human lung cancer cells.
2000
2000
Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.
The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of… 
1999
1999
Sets of aldolase antibodies with antipodal reactivities. Formal synthesis of epothilone E by large-scale antibody-catalyzed resolution of thiazole aldol.
[formula: see text] Three monoclonal aldolase antibodies, generated against a beta-diketone hapten by reactive immunization… 
1997
1997
Epothilone A induces apoptosis in neuroblastoma cells with multiple mechanisms of drug resistance.
Epothilone A, a novel macrolide antibiotic, is produced by the myxobacterium Sorangium cellulosum. Similarly to paclitaxel (Taxol… 
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