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Antibiotics: Actions, Origins, Resistance
- C. Walsh
- Biology, Chemistry
- 11 February 2003
This new text offers a comprehensive, up to date account of those structural classes of antibiotics that have had an impact in human infectious disease. While most of the attention is on natural…
Protein posttranslational modifications: the chemistry of proteome diversifications.
An understanding of the scope and pattern of the many posttranslational modifications in eukaryotic cells provides insight into the function and dynamics of proteome compositions.
A new enzyme superfamily - the phosphopantetheinyl transferases.
Molecular mechanisms that confer antibacterial drug resistance
- C. Walsh
- 17 August 2000
The authors live in an era when antibiotic resistance has spread at an alarming rate and dire predictions concerning the lack of effective antibacterial drugs occur with increasing frequency, so it is apposite to ask a few simple questions about these life-saving molecules.
Antibiotics for Emerging Pathogens
The emergence of multidrug resistance among the latest generation of pathogens suggests that the discovery of new scaffolds should be a priority, and promising approaches to scaffold discovery are emerging.
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The…
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
The mechanisms of siderophore biosynthesis follow the same fundamental enzymatic logic, which involves a series of elongating acyl-S-enzyme intermediates on multimodular protein assembly lines: nonribosomal peptide synthetases (NRPS).
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.
Christopher T. Walsh is the Hamilton Kuhn Professor of Biological Chemistry and Molecular Pharmacology (BCMP) at Harvard Medical School and has had extensive experience in academic administration, including Chairmanship of the MIT Chemistry Department and the HMS Biological Chemistry & molecular Pharmacology Department.
The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria
The identification of a MAA biosynthetic gene cluster in a cyanobacterium and the discovery of analogous pathways in other sequenced organisms are reported.
Functional association of cyclophilin A with HIV-1 virions
The association of cyclophilin A with HIV-1 virions was inhibited in a dose-dependent manner by cyclosporin A as well as by SDZ NIM811, a non-immunosuppressive analogue of cyclospora A, indicating that the association is functionally relevant.