• Publications
  • Influence
Antibiotics: Actions, Origins, Resistance
This new text offers a comprehensive, up to date account of those structural classes of antibiotics that have had an impact in human infectious disease. While most of the attention is on naturalExpand
A new enzyme superfamily - the phosphopantetheinyl transferases.
This work has identified a large family of proteins having 12-22 % similarity with ACPS, which are putative P-pant transferases, and found three of these proteins, E. coli EntD and o195, and subtilis Sfp, have been overproduced, purified and found to have P- pant transferase activity. Expand
Molecular mechanisms that confer antibacterial drug resistance
  • C. Walsh
  • Biology, Medicine
  • Nature
  • 17 August 2000
The authors live in an era when antibiotic resistance has spread at an alarming rate and dire predictions concerning the lack of effective antibacterial drugs occur with increasing frequency, so it is apposite to ask a few simple questions about these life-saving molecules. Expand
Antibiotics for Emerging Pathogens
The emergence of multidrug resistance among the latest generation of pathogens suggests that the discovery of new scaffolds should be a priority, and promising approaches to scaffold discovery are emerging. Expand
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. TheExpand
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.
Christopher T. Walsh is the Hamilton Kuhn Professor of Biological Chemistry and Molecular Pharmacology (BCMP) at Harvard Medical School and has had extensive experience in academic administration, including Chairmanship of the MIT Chemistry Department and the HMS Biological Chemistry & molecular Pharmacology Department. Expand
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
The mechanisms of siderophore biosynthesis follow the same fundamental enzymatic logic, which involves a series of elongating acyl-S-enzyme intermediates on multimodular protein assembly lines: nonribosomal peptide synthetases (NRPS). Expand
The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria
The identification of a MAA biosynthetic gene cluster in a cyanobacterium and the discovery of analogous pathways in other sequenced organisms are reported. Expand
Protein posttranslational modifications: the chemistry of proteome diversifications.
An understanding of the scope and pattern of the many posttranslational modifications in eukaryotic cells provides insight into the function and dynamics of proteome compositions. Expand
Opinion — anti-infectives: Where will new antibiotics come from?
  • C. Walsh
  • Biology, Medicine
  • Nature Reviews Microbiology
  • 1 October 2003
There is a constant need for new antibacterial drugs owing to the inevitable development of resistance that follows the introduction of antibiotics to the clinic. When a new class of antibiotic isExpand