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This new text offers a comprehensive, up to date account of those structural classes of antibiotics that have had an impact in human infectious disease. While most of the attention is on natural… Expand
The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of… Expand
BACKGROUND
All polyketide synthases, fatty acid synthases, and non-ribosomal peptide synthetases require posttranslational modification of their constituent acyl carrier protein domain(s) to become… Expand
Toward New Scaffolds Most existing antibiotics are derived from a small number of core molecular structures or scaffolds. As more and more pathogens emerge that are resistant to existing antibiotics,… Expand
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The… Expand
Advances in enzymology and related areas of…
Halogenoalkanesulfonic acid amides of the formula IN WHICH R and R' each independently is hydrogen, halogen, alkyl of up to 6 carbon atoms, or halogen-substituted alkyl of up to 6 carbon atoms, Hal… Expand
biotics of the penicillin and cephalosporin families, 3,4 as well as the glycopeptides of the vancomycin family 5 (Figure 1a). * To whom correspondence should be addressed: christopher_walsh@… Expand
SUMMARY The regulatory logic of siderophore biosynthetic genes in bacteria involves the universal repressor Fur, which acts together with iron as a negative regulator. However in other bacteria, in… Expand
Enzymes for Sunscreen Synthesis Many fungi, cyanobacteria, algae, and other marine organisms can biosynthesize small molecules termed mycosporine and mycosporine-like amino acids (MAAs) that, among… Expand