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Synthesis of site-specific antibody-drug conjugates using unnatural amino acids
Antibody-drug conjugates (ADCs) allow selective targeting of cytotoxic drugs to cancer cells presenting tumor-associated surface markers, thereby minimizing systemic toxicity. Traditionally, the drugExpand
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The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor
NADH:ubiquinone oxidoreductase (complex I) is the entry enzyme of mitochondrial oxidative phosphorylation. To obtain the structural information on inhibitor/quinone binding sites, we synthesizedExpand
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The Membrane Subunit NuoL(ND5) Is Involved in the Indirect Proton Pumping Mechanism of Escherichia coli Complex I*
Complex I pumps protons across the membrane by using downhill redox energy. Here, to investigate the proton pumping mechanism by complex I, we focused on the largest transmembrane subunit NuoLExpand
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Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells.
The ability to genetically incorporate unnatural amino acids (UAAs) at specific sites in the proteome of living cells provides a powerful tool to both investigate and engineer protein structure andExpand
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Withanolides of Datura metel
Abstract The leaves of Datura metel yielded three new withanolides in addition to lycium substance B, previously reported from other Datura species. The structures of the withanolides, clarified byExpand
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Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug.
Novel monomethylauristatin E (MMAE) prodrug 8 was designed and prepared that bound cell surface glycoprotein integrin αvβ3, and was activated using legumain protease as a catalyst. Upon activation,Expand
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Thermostable enzymes in organic synthesis, Part 6. Total synthesis of (S)–(–)-zearalenone using a TBADH-generated trifunctional chiron
Chiral alcohols produced by Thermoanaerobium brockii alcohol dehydrogenase (TBADH)-catalysed asymmetric reduction of polyfunctional ketones are useful building blocks for natural products synthesis.Expand
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Bidirectional regulation of Aβ levels by Presenilin 1
Significance Alzheimer’s disease is the most common neurodegenerative disorder, affecting more than 5 million people in the United States. Multiple lines of evidence suggest that the accumulation ofExpand
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Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage
Significance Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Four approved drugs are used to treat AD cognitive symptoms, including loss of short-term memory. These drugsExpand
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Bifurcation in a Nonlinear Autoparametric System Using Experimental and Numerical Investigations
Experimental and numerical investigations are carried out on anautoparametric system consisting of a composite pendulum attached to aharmonically base excited mass-spring subsystem. The dynamicExpand
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