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Epothilones

Known as: Epothilon, Epothilone, Epothilones [Chemical/Ingredient] 
A class of compounds isolated from the myxobacterium Sorangium cellulosum. Similar to taxanes, epothilone compounds induce microtubule polymerization… 
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (17)

(S)-14-methoxyepothilone12,13-desoxyepothilone FBMS 310705BMS-748285

Broader (3)

Antineoplastic AgentsThiazolesTubulin Modulators
In BloodNegative Regulation of Microtubule DepolymerizationProcess of secretionagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
STX140 Is Efficacious In vitro and In vivo in Taxane-Resistant Breast Carcinoma Cells
Purpose: The aim of these studies was to characterize the action of STX140 in a P-glycoprotein–overexpressing tumor cell line… 
Review
2008
Review
2008
The Epothilones: Translating from the Laboratory to the Clinic
The epothilones are macrolide compounds that have been shown to stabilize microtubules. The epothilones are strong promoters of… 
Review
2005
Review
2005
Recent developments in the chemical biology of epothilones.
Epothilones A and B are naturally occurring microtubule-stabilizers, which inhibit the growth of human cancer cells in vitro at… 
Highly Cited
2004
Highly Cited
2004
The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones.
Based on epothilones as powerful natural product leads several promising new anticancer agents have emerged through concerted… 
Highly Cited
2002
Highly Cited
2002
Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.
A concise modular laboratory construction of the epothilone class of promising antitumor agents has been accomplished. For the… 
Review
2002
Review
2002
The role of new agents in the treatment of non-small cell lung cancer.
Review
2001
Review
2001
Recent developments in the chemistry, biology and medicine of the epothilones.
The epothilones have occupied center stage on the scenes of total synthesis, chemical biology and medicine for the last five… 
2001
2001
Total synthesis of epothilones B and D.
[reaction: see text] A highly convergent total synthesis of the natural products epothilone B and D is described. The route is… 
Highly Cited
2000
Highly Cited
2000
Total syntheses of epothilones B and D.
Total syntheses of the microtubule stabilizing antitumor drugs epothilone B and D are described, starting from optically pure (S… 
Highly Cited
1998
Highly Cited
1998
Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones.
The directed evolution of an esterase from Pseudomonas fluorescens using the mutator strain Epicurian coli XL1-Red was… 
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