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Epothilones

Known as: Epothilon, Epothilone, Epothilones [Chemical/Ingredient] 
A class of compounds isolated from the myxobacterium Sorangium cellulosum. Similar to taxanes, epothilone compounds induce microtubule polymerization… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with… Expand
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Highly Cited
2015
Highly Cited
2015
Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms… Expand
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Highly Cited
2007
Highly Cited
2007
PURPOSE Ixabepilone (BMS-247550) is an epothilone analog that optimizes the properties of naturally occurring epothilone B… Expand
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Review
2004
Review
2004
Drugs that target microtubules are among the most commonly prescribed anticancer therapies. Although the mechanisms by which… Expand
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Highly Cited
2002
Highly Cited
2002
Laulimalide is a cytotoxic natural product that stabilizes microtubules. The compound enhances tubulin assembly, and laulimalide… Expand
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Highly Cited
2000
Highly Cited
2000
The epothilones are naturally occurring antimitotic drugs that share with the taxanes a similar mechanism of action without… Expand
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Highly Cited
2000
Highly Cited
2000
The polyketide epothilone is a potential anticancer agent that stabilizes microtubules in a similar manner to Taxol. The gene… Expand
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Highly Cited
1997
Highly Cited
1997
Epothilones A and B, natural products with minimal structural analogy to taxoids, have effects similar to those of paclitaxel… Expand
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Highly Cited
1997
Highly Cited
1997
Epothilones A and B, two compounds that have been recently isolated1 from myxobacterium Sorangium cellulosum strain 90, have… Expand
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Highly Cited
1995
Highly Cited
1995
Tubulin polymerization into microtubules is a dynamic process, with the equilibrium between growth and shrinkage being essential… Expand
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