Epothilones

Known as: Epothilon, Epothilone, Epothilones [Chemical/Ingredient] 
A class of compounds isolated from the myxobacterium Sorangium cellulosum. Similar to taxanes, epothilone compounds induce microtubule polymerization… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon… (More)
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2008
2008
Epothilones are a new class of antimicrotubule agents currently in clinical trials. Their chemical structures are distinct from… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Ixabepilone (BMS-247550) is an epothilone analog that optimizes the properties of naturally occurring epothilone B… (More)
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Review
2007
Review
2007
Microtubule-targeting agents such as the taxanes are highly active against breast cancer and have become a cornerstone in the… (More)
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Review
2004
Review
2004
Drugs that target microtubules are among the most commonly prescribed anticancer therapies. Although the mechanisms by which… (More)
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Highly Cited
2002
Highly Cited
2002
Laulimalide is a cytotoxic natural product that stabilizes microtubules. The compound enhances tubulin assembly, and laulimalide… (More)
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Highly Cited
2000
Highly Cited
2000
The epothilones are naturally occurring antimitotic drugs that share with the taxanes a similar mechanism of action without… (More)
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Highly Cited
1998
Highly Cited
1998
An important class of cellular proteins, which includes members of the p21ras family, undergoes posttranslational farnesylation… (More)
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Highly Cited
1997
Highly Cited
1997
Epothilones A and B, natural products with minimal structural analogy to taxoids, have effects similar to those of paclitaxel… (More)
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Highly Cited
1995
Highly Cited
1995
Tubulin polymerization into microtubules is a dynamic process, with the equilibrium between growth and shrinkage being essential… (More)
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