Tubulin Modulators

Taxanes are a family of natural products with a broad spectrum of anticancer activity. This activity is mediated by interaction… Expand

 

Microtubule inhibitors, as chemotherapeutic drugs, are widely used for cancer treatment in clinic. However, the development of… Expand

The development of cancer is often accompanied by a loss of the primary cilium, a microtubule-based cellular protrusion that… Expand

Imidazoles and benzimidazoles are privileged heterocyclic bioactive compounds used with success in the clinical practice of… Expand

Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background: Most cytotoxic agents are often broadly active… Expand

Previous studies have observed fluorescently labeled HIV particles tracking along microtubule networks for nuclear localization… Expand

BACKGROUND Microtubule-stabilising agents typified by the epothilone class of drug have demonstrated promising activity in Phase… Expand

Background: Microtubule-stabilising agents typified by the epothilone class of drug have demonstrated promising activity in Phase… Expand

Microtubule dynamics are regulated by a diverse array of factors. The net balance of two opposing activities largely determines… Expand