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Tubulin Modulators

Known as: Microtubule Modulators, Modulators, Microtubule, Modulators, Tubulin 
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
National Institutes of Health

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Related topics

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Narrower (31)

2-methoxyestradiolAlbendazoleBenomylColchicine
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In BloodMicrotubule Inhibitor [EPC]Microtubulesagonists
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
Taxanes are a family of natural products with a broad spectrum of anticancer activity. This activity is mediated by interaction… Expand
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2019
2019
Faculty Opinions recommendation of Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site.
 
2018
2018
A Novel Microtubule Inhibitor Overcomes Multidrug Resistance in Tumors.
Microtubule inhibitors as chemotherapeutic drugs are widely used for cancer treatment. However, the development of multidrug… Expand
2016
2016
Identification of drugs that restore primary cilium expression in cancer cells
The development of cancer is often accompanied by a loss of the primary cilium, a microtubule-based cellular protrusion that… Expand
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Review
2015
Review
2015
Imidazoles and benzimidazoles as tubulin-modulators for anti-cancer therapy.
Imidazoles and benzimidazoles are privileged heterocyclic bioactive compounds used with success in the clinical practice of… Expand
2014
2014
Abstract 1619: Hsp90 inhibitor drug conjugates (HDCs): Construct design and preliminary evaluation
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background: Most cytotoxic agents are often broadly active… Expand
2011
2011
Effects of Microtubule Modulators on HIV-1 Infection of Transformed and Resting CD4 T Cells
ABSTRACT Previous studies have observed fluorescently labeled HIV particles tracking along microtubule networks for nuclear… Expand
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Review
2008
Review
2008
Epothilones and new analogues of the microtubule modulators in taxane-resistant disease.
BACKGROUND Microtubule-stabilising agents typified by the epothilone class of drug have demonstrated promising activity in Phase… Expand
Review
2008
Review
2008
Epothilones and new analogues of the microtubule modulators in taxane-resistant disease
Background: Microtubule-stabilising agents typified by the epothilone class of drug have demonstrated promising activity in Phase… Expand
2000
2000
A dynamic duo of microtubule modulators
  • R. Heald
  • Nature Cell Biology
  • 2000
    • Corpus ID: 21092753
Microtubule dynamics are regulated by a diverse array of factors. The net balance of two opposing activities largely determines… Expand
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