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Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-tubulin complexes, providing spatial and… Expand Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted… Expand Reversible acetylation of α-tubulin has been implicated in regulating microtubule stability and function. The distribution of… Expand Evaluation of the electrostatic properties of biomolecules has become a standard practice in molecular biophysics. Foremost among… Expand Microtubules are long, proteinaceous filaments that perform structural functions in eukaryotic cells by defining cellular shape… Expand A monoclonal antibody to the microtubule-associated protein tau (tau) labeled some neurofibrillary tangles and plaque neurites… Expand We report here that microtubules in vitro coexist in growing and shrinking populations which interconvert rather infrequently… Expand TAXOL (Fig. 1) was isolated from the plant Taxus brevifolia (western yew) by Wani et al., who reported that the molecule has… Expand A heat stable protein essentail for microtubule assembly has been isolated. This protein, which we designate tau (tau), is… Expand Microtubule assembly is enhanced by the addition of 1 M sucrose or 4 M glycerol to the reassembly mixture. Tubulin can be… Expand