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The ability of a eukaryotic cell to resist deformation, to transport intracellular cargo and to change shape during movement… Expand Metastatic cancers, once established, are the primary cause of mortality associated with cancer. Previously, we used a genomic… Expand Phosphoinositides [PPIs, which collectively refer to phosphorylated derivatives of phosphatidylinositol (PI)] have a pivotal role… Expand Tight junctions are one mode of cell–cell adhesion in epithelial and endothelial cellular sheets. They act as a primary barrier… Expand Type-A receptors for the neurotransmitter GABA (γ-aminobutyric acid) are ligand-gated chloride channels that mediate inhibitory… Expand The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a… Expand The three-dimensional intracellular network formed by the filamentous polymers comprising the cytoskeletal affects the way cells… Expand To move forward, migrating cells must generate traction forces through surface receptors bound to extracellular matrix molecules… Expand Mechanical stresses were applied directly to cell surface receptors with a magnetic twisting device. The extracellular matrix… Expand Actin stress fibers are one of the major cytoskeletal structures in fibroblasts and are linked to the plasma membrane at focal… Expand