• Publications
  • Influence
Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors
It is shown that activation of endogenous progenitors leads to massive regeneration of hippocampal pyramidal neurons after ischemic brain injury, expanding the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases. Expand
Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro
These findings indicate that neuronal precursor cells can be isolated from ES cells and that these cells can efficiently differentiate into functional post-mitotic neurons of diverse CNS structures. Expand
Altered microtubule organization in small-calibre axons of mice lacking tau protein
The results argue against the suggested role of tau in axonal elongation but confirm that it is crucial in the stabilization and organization of axonal microtubules in a certain type of axon. Expand
Differential Control of Postsynaptic Density Scaffolds via Actin-Dependent and -Independent Mechanisms
A critical role of filamentous actin is indicated in determining the extent of dynamic reorganization in PSD molecular composition and genetic manipulations eliminating either NMDA receptors or metabotropic glutamate receptors did not primarily influence mobility of their binding scaffolds. Expand
Spine Formation and Correlated Assembly of Presynaptic and Postsynaptic Molecules
The local and stepwise assembly of synaptic components at the contact sites between dendritic protrusions and axons explains the developmental remodeling of excitatory synapses. Expand
The RNA Binding Protein TLS Is Translocated to Dendritic Spines by mGluR5 Activation and Regulates Spine Morphology
TLS participates in mRNA sorting to the dendritic spines induced by mGluR5 activation and regulates spine morphology to stabilize the synaptic structure, and is recruited to dendrites not only via microtubules but also via actin filaments. Expand
Rapid Redistribution of the Postsynaptic Density Protein PSD-Zip45 (Homer 1c) and Its Differential Regulation by NMDA Receptors and Calcium Channels
D-Zip45 showed rapid redistribution and a higher steady-state turnover rate and neuronal activity differentially redistributes a specific subset of PSD proteins, which are important for localization of both surface receptors and intracellular signaling complexes. Expand
Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau.
The results suggest that neuronal microtubule-associated proteins introduced into fibroblasts by cDNA transfection stabilize microtubules and affect the state of post-translational modification of tubulin. Expand
Molecular anatomy of the postsynaptic density
  • S. Okabe
  • Medicine, Biology
  • Molecular and Cellular Neuroscience
  • 1 April 2007
The structure and molecular composition of the postsynaptic density as well as the molecular interactions between the major constituents are described, combined with recent quantitative analyses of the PSD protein contents per synapse, in order to provide a current view of thePSD molecular architecture and its dynamics. Expand
Continual remodeling of postsynaptic density and its regulation by synaptic activity
Continual PSD turnover and its regulation by synaptic activity may be important in activity-dependent remodeling of neuronal connections. Expand